A Definition of Thymic-Dependent Areas in the Peripheral Lymphoid Tissues of Rabbits (Part 1 of 2)

Identification of the Bursa-dependent and Thymusdependent Areas in the Tonsilla Caecalis of Chickens

“…In this investigation, too, similar thymus-irradiated chickens were used as chickens deficient in thymus-dependent lymphoid system. The thymus-dependent areas of the spleen, lymph node, Peyer's patch and appendix have been described in thymectomized rats (Waksman et al 1962), mice (Parrott et al 1966), rabbits (Hanaoka et al 1967;Sutherland et al 1970) and in mice with congenital aplasia of the thymus (De Sousa et al 1969). It has been demonstrated that in mammals the thymus-dependent areas are occupied by the members of recirculating lymphocyte pool the majority of which consist of small lymphocytes (Gowans and Knight 1964;Parrott et al 1966;Goldschneider and McGregor 1968;Miller 1969).…”

Development of the rabbit appendix

“…No more fully differentiated plasma cells were seen. The absence of plasma cells in immunologically significant numbers also has been reported in antigenically stim ulated animals [Hanaoka and Waksman, 1970], Although the appendix has T-cell populations [Sutherland et al, 1970;Waks man et al, 1973], this lack of plasma cells is inconsistent with classifying the appendix as a peripheral tissue with cells capable of ¡incit ing a humoral immune response in situ. Sutherland et at.…”

Inhibition of the Germinal Center Formation in

“…1966), rats (Waksman et al 1962;Gowans and Knight 1964) and rabbits (Hanaoka et al . 1967;Sutherland et al 1970). In these animals and other rodents , it is yet obscure whether germinal centers exhibit any specific localization of their appearance in the lymph nodes or in the spleens .…”