A decade of human genome project conclusion: Scientific diffusion about our genome knowledge

Moraes, Fernanda; Góes, Andréa Carla de Souza

doi:10.1002/bmb.20952

Cited by 92 publications

(56 citation statements)

References 23 publications

(19 reference statements)

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“…The Human Genome Project was initiated in 1990 and was completed in 2003, with the joint efforts of scientists in many countries, public programs and private companies in order to expose all genes in the human genome (2). An important outcome of the Human Genome Project was that electronically compiled genomic data could be used to identify desired genes in certain parts of the genome (Fig.1).…”

Section: Recent Developments In Geneticsmentioning

confidence: 99%

Future Biotechnology

Dündar

Prakash

Lal

et al. 2019

The EuroBiotech Journal

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The field of biotechnology is large and could be considered tritely as simply the development of technology that is based on biology. It is clear that the concepts of biotechnology can spread to cover many different fields of application and so the future developments in biotechnology will be similarly wide-ranging across many fields of applications. Here we focus onto medical biotechnology and further refine our discussion onto considering aspects of genetics and nanotechnologies that could impact on the development of future biotechnologies in the medical field. These areas that we consider in this brief article provide the basis for a panel discussion on Future Biotechnology at the European Biotechnology Congress held in Valencia, Spain in April 2019.

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Section: Recent Developments In Geneticsmentioning

confidence: 99%

Future Biotechnology

Dündar

Prakash

Lal

et al. 2019

The EuroBiotech Journal

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“…Following the completion of the Human Genome Project in April 2003 (18), a pursuit of more powerful methodologies of sequencing the entire genome resulted in improvements to all steps of the sequencing pipeline, from bench work to bioinformatics. With a highly competitive market, innovative sequencing hardware and services advanced rapidly with increasing accuracy and decreasing costs.…”

Section: New Research Technologies and Environmental Healthmentioning

confidence: 99%

Future of environmental research in the age of epigenomics and exposomics

Holland¹

2017

Reviews on Environmental Health

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Abstract Environmental research and public health in the 21st century face serious challenges such as increased air pollution and global warming, widespread use of potentially harmful chemicals including pesticides, plasticizers, and other endocrine disruptors, and radical changes in nutrition and lifestyle typical of modern societies. In particular, exposure to environmental and occupational toxicants may contribute to the occurrence of adverse birth outcomes, neurodevelopmental deficits, and increased risk of cancer and other multifactorial diseases such as diabetes and asthma. Rapidly evolving methodologies of exposure assessment and the conceptual framework of the Exposome, first introduced in 2005, are new frontiers of environmental research. Metabolomics and adductomics provide remarkable opportunities for a better understanding of exposure and prediction of potential adverse health outcomes. Metabolomics, the study of metabolism at whole-body level, involves assessment of the total repertoire of small molecules present in a biological sample, shedding light on interactions between gene expression, protein expression, and the environment. Advances in genomics, transcriptomics, and epigenomics are generating multidimensional structures of biomarkers of effect and susceptibility, increasingly important for the understanding of molecular mechanisms and the emergence of personalized medicine. Epigenetic mechanisms, particularly DNA methylation and miRNA expression, attract increasing attention as potential links between the genetic and environmental determinants of health and disease. Unlike genetics, epigenetic mechanisms could be reversible and an understanding of their role may lead to better protection of susceptible populations and improved public health.

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“…As a result, a number of novel features of mammalian genomes were uncovered, most of which were against the expectation of scientists. For example, the number of protein-coding genes in the human genome turned out to be approximately 20,000 [1], which is comparable to, and even less than, that in the murine genome. Regarding the organization of the human genome, the area used for encoding those proteins is as much as 2%, whereas 55% of the whole genome is occupied by repetitive sequences [2].…”

Section: Introductionmentioning

confidence: 97%

Retrotransposons Manipulating Mammalian Skeletal Development in Chondrocytes

Kubota

Ishikawa

Kawata

et al. 2020

IJMS

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Retrotransposons are genetic elements that copy and paste themselves in the host genome through transcription, reverse-transcription, and integration processes. Along with their proliferation in the genome, retrotransposons inevitably modify host genes around the integration sites, and occasionally create novel genes. Even now, a number of retrotransposons are still actively editing our genomes. As such, their profound role in the evolution of mammalian genomes is obvious; thus, their contribution to mammalian skeletal evolution and development is also unquestionable. In mammals, most of the skeletal parts are formed and grown through a process entitled endochondral ossification, in which chondrocytes play central roles. In this review, current knowledge on the evolutional, physiological, and pathological roles of retrotransposons in mammalian chondrocyte differentiation and cartilage development is summarized. The possible biological impact of these mobile genetic elements in the future is also discussed.

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A decade of human genome project conclusion: Scientific diffusion about our genome knowledge

Cited by 92 publications

References 23 publications

Future Biotechnology

Future Biotechnology

Future of environmental research in the age of epigenomics and exposomics

Retrotransposons Manipulating Mammalian Skeletal Development in Chondrocytes

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