A decade of HPLC–MS/MS in the routine clinical laboratory — Goals for further developments

Vogeser, Michael; Seger, Christoph

doi:10.1016/j.clinbiochem.2008.02.017

Cited by 192 publications

(105 citation statements)

References 83 publications

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“…High analytical specificity, simple sample preparation, and high throughput are typical strengths of LC-MS/MS technology used for therapeutic drug monitoring (13). High analytical precision is, however, not a strength of this technology.…”

Section: Discussionmentioning

confidence: 99%

A routine method for the quantification of the novel antimycotic drug posaconazole in plasma using liquid chromatography-tandem mass spectrometry

Vogeser

Rieger²,

Ostermann³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: Posaconazole is now widely used for prophylaxis of invasive fungal infections in immunocompromised patients. The pharmacokinetic properties of the drug argue for therapeutic monitoring, but so far described analytical methods have shortcomings with respect to application in a routine setting. The aim of our work was to develop an analytical method suitable for routine use. Methods: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used. For sample preparation, protein precipitation followed by on-line solid phase extraction was used. SCH 56984, a posaconazole related compound provided by the manufacturer of posaconazole, was used as internal standard.

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Section: Discussionmentioning

confidence: 99%

A routine method for the quantification of the novel antimycotic drug posaconazole in plasma using liquid chromatography-tandem mass spectrometry

Vogeser

Rieger²,

Ostermann³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…However the widespread application of this technology requires substantial further development until it can be used as a routine instrument in the setting of clinical laboratories (Vogeser and Seger, 2008). High-level reference method protocols should be developed through inter-laboratory collaboration (Thienpont et al, 2008).…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Steroid measurement with LC–MS/MS in pediatric endocrinology

Rauh

2009

Molecular and Cellular Endocrinology

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Please cite this article as: Rauh, M., Steroid measurement with LC-MS/MS in pediatric endocrinology, Molecular and Cellular Endocrinology (2008), doi:10.1016/j.mce.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…For TDM purposes, LC-MS/MS has been regarded as technically superior over immunoassays and UV based HPLC/UV methods because of its better specificity and sensitivity, lack of interference or matrix effects [18].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic drug monitoring of carbamazepine and its metabolite in children from dried blood spots using liquid chromatography and tandem mass spectrometry

Shokry

Villanelli

Malvagia

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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A decade of HPLC–MS/MS in the routine clinical laboratory — Goals for further developments

Cited by 192 publications

References 83 publications

A routine method for the quantification of the novel antimycotic drug posaconazole in plasma using liquid chromatography-tandem mass spectrometry

A routine method for the quantification of the novel antimycotic drug posaconazole in plasma using liquid chromatography-tandem mass spectrometry

Steroid measurement with LC–MS/MS in pediatric endocrinology

Therapeutic drug monitoring of carbamazepine and its metabolite in children from dried blood spots using liquid chromatography and tandem mass spectrometry

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