A Dangerous Cup of Tea

Canders, Caleb P.; Stanford, Steve R.; Chiem, Alan

doi:10.1016/j.wem.2013.11.002

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…A cosmetic ingredient review expert panel concluded that there was insufficient data regarding the safety of arnica; however, the 24 It was also found that a patient developed a contact dermatitis to an arnica extract but not the ointment formulation, which was likely due to differences in concentration, vehicle, and other additives. 25 In stark contrast to these experiences, there were no serious adverse effects noted in the dilute homeopathic doses studied in recent reviews.…”

Section: Sa Fe T Ymentioning

confidence: 99%

“…A cosmetic ingredient review expert panel concluded that there was insufficient data regarding the safety of arnica; however, the homeopathic diluted remedy has been generally recognized to be safe by the FDA 4,23 . Case reports exist of patients ingesting home‐made preparations of arnica with resultant systemic symptoms of respiratory distress, tachyarrhythmias, and gastrointestinal hemorrhage 24 . It was also found that a patient developed a contact dermatitis to an arnica extract but not the ointment formulation, which was likely due to differences in concentration, vehicle, and other additives 25 .…”

Section: Safetymentioning

confidence: 99%

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Growing role for arnica in cosmetic dermatology: Lose the bruise

Sherban

Wang

Geronemus

2021

J of Cosmetic Dermatology

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Postoperative skincare outcomes are of particular interest to dermatologists, especially with cosmetic surgeries and treatments using injectables, lasers, and other energy-based devices. Over the years, efforts have been made to reduce postprocedural edema and ecchymosis. 1 Although no standardized interventions are currently widely accepted to manage these potential events, homeopathic medications have continued to be investigated. They have relevance due to their often more affordable cost and low-risk safety profile. 2,3 Arnica is a traditional homeopathic remedy, which has been investigated and used by many physicians to reduce the morbidity associated with various procedures. 2,3 Although larger and recent clinical trials are limited, we review the relevant information on arnica and offer our own insights into its use in order to shed more light on its periprocedural utility. | BACKG ROU N DArnica is derived from plants of the Asteraceae family. Its compounds have traditionally been used to manage inflammation, ecchymosis, and hematomas. [1][2][3][4][5][6] Arnica montana is native to Europe and North America, and it is the most common source of arnica, which is derived from the dried flowers and roots. 3 The German Commission E, which is a scientific advisory board of their Federal Institute for Drugs and Medical Devices, has already approved arnica for the management of hematomas, ecchymosis, and edema, and primary care practices in Germany have been utilizing this remedy without significant reported adverse effects. 3,5 The United States Federal Drug Administration (FDA) has deemed oral arnica to be safe; however, controversy remains as to whether it is effective and which procedures are most suitable for its use. 3,7 | MECHANIS MThe mechanism of action for arnica is not yet entirely understood, but in vitro studies have shown it to possess various anti-inflammatory properties through inhibition of histamine release from degranulated mast cells, reduction of serotonin release from platelets, and decreased production of prostaglandins, including thromboxane B2. 3,5 Arnica has high concentrations of sesquiterpene lactones, such as helenalin, 11a,13-dihydrohelenalin, and chamissonolid, which have been linked to several anti-inflammatory activities that may be responsible for its role in reducing post-treatment edema and ecchymosis. 5 These

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Section: Sa Fe T Ymentioning

confidence: 99%

Section: Safetymentioning

confidence: 99%

Growing role for arnica in cosmetic dermatology: Lose the bruise

Sherban

Wang

Geronemus

2021

J of Cosmetic Dermatology

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“…Two hours after drinking the tea, the patient experienced tachycardia, watery emesis, and epigastric tenderness. After receiving intravenous fluids and antiemetics, the patient was stabilized [59].…”

Section: Plants and Plant Constituents Associated With Cardiovascularmentioning

confidence: 99%

A Review of the Toxicity of Compounds Found in Herbal Dietary Supplements

et al. 2018

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Use of herbal dietary supplements by the public is common and has been happening for centuries. In the United States, the Food and Drug Administration has a limited scope of regulation over marketed herbal dietary supplements, which may contain toxic botanical compounds that pose a public health risk. While the Food and Drug Administration has made efforts to prohibit the sale of unsafe herbal dietary supplements, numerous reports have proliferated of adverse events due to these supplements. This literature review investigates bioactive plant compounds commonly used in herbal dietary supplements and their relative toxicities. Using primarily the National Library of Medicine journal database and SciFinder for current reports, 47 toxic compounds in 55 species from 46 plant families were found to demonstrate harmful effects due to hepatic, cardiovascular, central nervous system, and digestive system toxicity. This review further contributes a novel and comprehensive view of toxicity across the botanical dietary market, and investigates the toxicity of the top ten botanical dietary supplements purchased in the United States of America to gauge the exposure risk of toxicity to the public. The criteria of measuring toxicity in this review (plant compound, family, quantity, and toxicity effects) across the entire market in the United States, with special attention to those supplements whose exposure to the consumer is maximal, provides a unique contribution to the investigation of botanical supplements.

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“…Furthermore, S. microglossia has been included in the List of Medicinal Plants of Interest to the Brazil`s Unified Health System -RENISUS (BRASIL, 2009). However, the safety of the systemic use of arnica tisanes and tinctures has been questioned by both the academic and medical communities (Hudson et al, 2018), especially due to reports of poisoning or intoxication (Bertin, 1864;Canders et al, 2014;Colombo et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A administração sistêmica de extratos de arnica é segura? Uma revisão sistemática de ensaios pré-clínicos

Oliveira¹,

Thomaz²,

Chequer³

et al. 2021

RSD

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Os extratos de “Arnica” são amplamente usados na medicina popular para tratar doenças inflamatórias agudas e crônicas. No entanto, seus efeitos tóxicos mediante uso sistêmico ainda não são totalmente compreendidos. Portanto, este trabalho fornece uma revisão sistemática sobre a segurança de extratos de arnica em ensaios pré-clínicos cobrindo sua administração oral e intraperitoneal em modelos animais. Para tanto, a diretriz PRISMA foi seguida e o protocolo do estudo foi registrado no PROSPERO (CDR42020167112). As pesquisas foram realizadas nas bases de dados PubMed (MEDLINE), Scopus, Science Direct, Web of Science (Science Citation Index) e Biblioteca Virtual da Saúde (BVS); enquanto a ferramenta de risco de viés do SYRCLE e o checklist CAMARADES foram usadas para avaliar a qualidade científica. De 382 artigos, cinco estudos atenderam aos critérios de elegibilidade e foram submetidos à análise qualitativa. Dados de toxicidade aguda foram relatados em todos os artigos selecionados, e o tempo de tratamento foi de até 14 dias. Além disso, as seguintes espécies foram relatadas: Solidago chilensis (categorias de perigo de 4 e 5 para administração i.p e v.o, respectivamente); Solidago microglossa (categoria de perigo de 3, i.p); Lychnophora trichocarpha (categoria de perigo ≥ 4, i.p); e Lychnophora pinaster (categoria de perigo ≥ 4, v.o). Os extratos alcoólicos apresentaram maior potencial tóxico, que aumentou de forma dose-dependente após 100 mg/Kg. Com relação à toxicidade órgão-específico, os artigos relataram hepatotoxicidade e nefrotoxicidade após análise histopatológica. No entanto, a segurança de S. chilensis, L. pinaster, L. trichocarpha e S. microglossa após a administração sistêmica permanece incerta devido à qualidade experimental limitada dos artigos incluídos, bem como a falta de relatos sobre toxicidade crônica, farmacocinética e estudos de mutagenicidade.

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A Dangerous Cup of Tea

Cited by 3 publications

References 4 publications

Growing role for arnica in cosmetic dermatology: Lose the bruise

Growing role for arnica in cosmetic dermatology: Lose the bruise

A Review of the Toxicity of Compounds Found in Herbal Dietary Supplements

A administração sistêmica de extratos de arnica é segura? Uma revisão sistemática de ensaios pré-clínicos

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