A Cytotoxic Lipopeptide from the Sponge-Derived Fungus Aspergillus versicolor

Lee, Yoon-Mi; Dang, Hung; Hong, Jeong-Hwa; Lee, Chong‐O.; Bae, Kyung-Sook; Kim, Dong‐Kyoo; Jung, Jee-Hyun

doi:10.5012/bkcs.2010.31.01.205

Cited by 50 publications

(28 citation statements)

References 16 publications

(19 reference statements)

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“…The fungal genus Aspergillus has been reported to produce a considerable number of cytotoxic compounds as well as other bioactive compounds (Belofsky et al, 1998;Fremlin et al, 2009). A previous study searching for bioactive metabolites from the marine sponge-derived fungus, Aspergillus versicolor, yielded three polyketides (Lee et al, 2007). In a continuing study on the same fungus, an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivityguided fractionation.…”

Section: Introductionmentioning

confidence: 99%

Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor

et al. 2010

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As part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41-4.61 microg/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78-6.25 microg/mL.

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Section: Introductionmentioning

confidence: 99%

Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor

et al. 2010

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“…To cite a few examples Aspergillus niger elaborates seven new diterpenoids [29], Aspergillus versicolor synthesises a novel lipopeptide [25] Aspergillus elaborates many polyketides, nonribosomal peptides, isoprenoids and lipopeptides of pharmaceutical importance [30] and is an ideal platform for expressing many other fungal and non-fungal metabolites [31,32 ] moreover, the molecular regulation of secondary metabolism in the model organism Aspergillus nidulans Winter is very well understood [33,34]. Such background knowledge of the secondary metabolism of this genus will help significantly in exploring the chemical diversity of microbe symbiotic .…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Marine Fungal Symbiont Isolated from Soft Coral Sinularia sp. from Panjang Island as Antifungal

Putri

Radjasa

Pringgenies

2015

Procedia Environmental Sciences

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Soft corals are invertebrates living on coral reefs that produce bioactive compound that can be used such as an antibacterial, antifungal, anti-tumor,and anti inflamantory that are beneficial for the pharmaceutical industry. Several studies have shown that fungi are very rich of natural chemical compounds that are potential as a source of new drugs, but there is few research in marine fungal symbionts. In this research we collecteda soft coralSinularia sp. as source of marine fungal symbionts from Panjang island of the North Java Sea.A total of15 fungi were successfully isolated and screened usingoverlay method against pathogenic fungiCandida Albicans and Aspergillus flavus.The results revealed that a fungalsymbiont was able to inhibit the growth of pathogenic fungi. Phytochemical tests showed that phenolic, triterpenoid and flavanoid compounds were detected within fungal extract. Molecular identification based on 18s rRNA gene showed that the active fungal was closely related to Aspergillus unguis.

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“…In some cases, these microorganisms and not sponge cells are the likely source of the secondary metabolites of interest 29,30,31 . It is reported that sponge hosted diverse microorganisms are metabolically very active in their respective host and it was demonstrated by comparing 16S rRNA gene derived sequence 32 .…”

Section: Marine Sponge Secondary Metabolitesmentioning

confidence: 99%

“…The fungus Aspergillus versicolor, isolated from Petrosia sp. (Jeju Island, Korea) yielded three known polyketides such as decumbenones A, B and versiol, and the cytotoxic lipopeptide fellutamide C 30 .…”

Section: Marine Sponge Secondary Metabolitesmentioning

confidence: 99%

Untitled

2012

IJPSR

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Marine sponges, the sessile invertebrates of the Phylum porifera are invaluable tool in current research. They remain as a goldmine to chemist and pharmacologist due to its defensive weapons, the secondary metabolites. Endogenous peptides from marine sponges and associated microorganisms are promising lead compound for drug development. Some of the compounds are under clinical trials. These peptides can act against variety of diseases in humans including bacterial, fungal, protozoan, HIV, inflammatory and even tumor. This review focuses on sponge symbiotic association with other organisms, significance of peptides as secondary metabolites and its pharmacological effects by highlighting its role as antbacterial, anti-fungal, anti-HIV and anti-tumor agents. Sponge-microbial associations are found to be very specific in the production of particular bioactive compounds.

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A Cytotoxic Lipopeptide from the Sponge-Derived Fungus Aspergillus versicolor

Cited by 50 publications

References 16 publications

Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor

Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor

Effectiveness of Marine Fungal Symbiont Isolated from Soft Coral Sinularia sp. from Panjang Island as Antifungal

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