A cyclometalated iridium(III) complex that inhibits the migration and invasion of MDA-MB-231 cells

Wang, Jinquan; Hou, Xue‐Long; Zhao, Zizhuo; Bo, Huaben; Chen, Qizhu

doi:10.1016/j.inoche.2016.02.018

Cited by 10 publications

(2 citation statements)

References 13 publications

(14 reference statements)

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“…24 ROS-mediated pathways can treat cancer by inducing damage to DNA, resulting in activating apoptotic pathways. 25 Our results indicated that the biosynthesized IrO 27 The combined treatment of Ir and Fe ions inhibits the migration of cells. The previous studies have shown that cell cycle regulation and inhibition played a role in cancer management.…”

Section: ■ Discussionmentioning

confidence: 70%

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Specific Oxide Nanoclusters Enhance Intracellular Reactive Oxygen Species for Cancer-Targeted Therapy

et al. 2020

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Bio-nanotechnology based cancer therapeutics exponentially increase every year. A therapeutic strategy to induce intracellular reactive oxygen species (ROS) has received promising success in oncotherapy. In this study, the new strategy has been exploited by the treatment of iridium (Ir) and Fe 2+ ions with cancer cells to biosynthesize the biocompatible fluorescent iridium oxide (IrO 2 ) and iron oxide nanoclusters (NCs) under the specific redox heterogeneous microenvironment of these diseased cells and tumors. The hydroxyl radical produced by the presence of Fe 2+ and H 2 O 2 in cancer cells apparently increased the ROS level in cancer cells during the process of biosynthesized NCs and, hence, simultaneously instigated apoptosis of relevant cells. Therefore, intracellular ROS-mediated in situ biosynthesis of IrO 2 and iron oxide NCs may also act as anticancer agents and provide a promising pathway for targeted cancer therapy.

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Section: ■ Discussionmentioning

confidence: 70%

“…When the tumor acidic microenvironment is used as an advantage, the biosynthesized NCs may potentially endow targeted therapeutic properties. The migration of cancer cells showed a potential role in cancer metastasis . The combined treatment of Ir and Fe ions inhibits the migration of cells.…”

Section: Discussionmentioning

confidence: 99%