“…To demonstrate the synthetic utility of this method, we conducted the practical total synthesis of antibiotic carbazomycin A ( 9 ), which was originally isolated from Streptomyces Strain H 1051-MY 10 by Nakamura and co-workers in 1980 (Scheme ). The biological activity of carbazomycin A and its unique structure, bearing the fully substituted benzene moiety, have attracted the attention of synthetic chemists, leading to eleven total syntheses over the recent decades Our synthesis commenced with C–H arylation of symmetrical chloroarene 10 using the established conditions. Thus, the combination of LiTMP and ZnCl 2 ·TMEDA provided the organozinc species 11 without aryne formation, which underwent Negishi coupling with 2-iodoaniline to give 2-aminobiphenyl 12 in 65% yield.…”