Iodine-promoted synthesis of CF₃-substituted dihydroimidazobenzimidazole and CF₃-dihydroimidazoindole via C–N bond formation

Abstract

The iodine-promoted cyclization of various N-(2-CF3-2-NHTs)ethylbenzimidazoles and N-(2-CF3-2-NHTs)ethylindoles proceeded smoothly and efficiently under mild basic conditions.

A SmI2-mediated reductive cyclisation reaction using the trifluoroacetamide group as the radical precursor

“…13 Therefore, the synthesis of 2-trifluoromethylindolines and 2-trifluoromethylindoles has recently attracted much attention, and various approaches have been reported. 14…”