A cyclic lipodepsipeptide, a spirolactone, and a chromanone from the marine fungus Verruculina enalia (Kohlm.) Kohlm. & Volkm.-Kohlm. BCC 22226

Marine natural products

“…279 Verruculina enalia yielded a cyclic lipodepsipeptide 783, rosigenin derivative 784 and 7-O-methylaposphaerin C 785. 280 Total synthesis of the proposed structure of chaunopyran A implied that revision of the absolute conguration to 786 is required, 281 whilst total synthesis of penicitide A both revised the previous partial stereochemical assignment and established the absolute conguration as 787. 282 Convergent and biomimetic syntheses of penicimutanin A, penicimutanolone and penicimutatin established the absolute congurations as 788-790 respectively 283 and syntheses of peribysins A-C and F-G revised the stereochemistry of peribysins A, C, F and G (to 791-794 respectively) and represented the rst syntheses of peribysins C, F and G. 284 Six step syntheses of the proposed and revised structures of (À)-versiquinazoline H led to correction of stereochemistry and the assignment of the absolute conguration as 795.…”

“…279 Verruculina enalia yielded a cyclic lipodepsipeptide 783 , rosigenin derivative 784 and 7- O -methylaposphaerin C 785 . 280…”

Endofungal bacteria boost anthelminthic host protection with the biosurfactant symbiosin

“…Interestingly, symbiosin is structurally similar to the known natural products colisporifungin (4), ophiotine ( 5), verruculin (6), and aselacine A (7) (Figure 3A and B). [36][37][38][39] It is remarkable that all of these compounds (4-7) have been isolated from fungi of the phylum Ascomycota, which are not described to harbor endosymbionts. Except for the terminal amino acids that are involved in lactone ring formation, the peptide backbones of lipopeptides 3-7 are almost identical.…”

Screening of Marine Bioactive Antimicrobial Compounds for Plant Pathogens

“…This compound broadly inhibits the growth of plant pathogens such as R. solani , F. graminearum , and P. sojae [ 129 ], therefore could be developed as a broad-spectrum fungicide. The compound (-)-cercosporamide ( 50 ) was extracted from another marine fungus Verruculina enalia BCC 22226, which shows antifungal activity towards M. oryzae and C. acutatum [ 20 ] and makes compound 50 a candidate for developing antifungal agents.…”

“…Thus far, scientists have isolated numerous natural products with antitumor, antibacterial, and other biological activities from marine organisms [ 12 , 15 , 16 , 17 , 18 , 19 ]. Modern pharmacological studies also demonstrate that many marine biological metabolites show good effects on killing phytopathogenic bacteria, which possibly can be used for developing biological fungicides [ 20 , 21 , 22 , 23 , 24 ]. In fact, at the present, marine organisms have become an important resource for developing new biological fungicides to control plant diseases.…”