A current status of adaptogens: natural remedy to stress

Pawar, Vinod S; Hugar, Shivakumar

doi:10.1016/s2222-1808(12)60207-2

Cited by 31 publications

(20 citation statements)

References 36 publications

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“…In ayurvedic and other traditionally known Indian systems of medicine, A. paniculata is often used as a tonic or rejuvenating herb in combination with other herbs and minerals. Several such medicinal plants are now pharmacologically classified as stress response modulators or adaptogenic herbs (Panossian & Wikman 2009;Pawar & Shivakumar 2012). Recent observations in our laboratories have not only revealed adaptogens like stress response modulating, anxiolytic, antidepressant activities of a medicinally used A. paniculata extract and andrographolide, but also have reconfirmed their anti-hyperglycemic activities in diabetic rats Thakur et al 2014aThakur et al ,2014bThakur et al ,2015Thakur, Soni, et al 2014).…”

Section: Introductionmentioning

confidence: 97%

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

Thakur

Rai

Chatterjee³

et al. 2016

Pharmaceutical Biology

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Context Andrographolide containing Andrographis paniculata (Burm. F.) Wall. Ex Nees (Acanthaceae) extracts is often used for treatments of diabetes and other inflammatory disorders commonly accompanying cognitive and other psychiatric disorders.Objective To compare the efficacies of a standardised A. paniculata extract (AP) and pure andrographolide on cognitive functions, oxidative stress and cholinergic function in diabetic rats. Materials and methods Streptozotocin-induced diabetic Charles Foster albino rats treated orally with a hydro-methanolic A. paniculata leaf extract (50, 100 and 200 mg/kg/day), or with pure andrographolide (15, 30 and 60 mg/kg/day) for 10 consecutive days, were subjected to Morris water maze test. After the test, acetylcholinesterase, superoxide dismutase (SOD), and catalase (CAT) activities and lipid peroxidation (LPO) in brain tissues were assessed. Results Acetylcholinesterase activity in pre-frontal cortex and hippocampus of diabetic rats was 2.1 and 2.6 times higher compared to nondiabetic rats. LPO was 1.6 times higher and decreased SOD (56.3%) and CAT (44.9%) activities in pre-frontal cortex of diabetic rats compared to nondiabetic rats. AP or andrographolide treatments dose dependently attenuated cognitive deficits, reduced acetylcholinesterase activity, oxidative stress, improved diabetic hyperglycemia and insulin deficiency. All observed effects of AP were quantitatively almost equal to those expected from its analytically quantified andrographolide content. Discussion and conclusion Reported observations are the very first ones suggesting beneficial effects of andrographolide against diabetes associated cognitive deficits, increased acetylcholinesterase activity and deteriorated antioxidative status. Efforts to exploit A. paniculata extracts enriched in andrographolide as preventive measures against such disorders can be warranted. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 97%

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

Thakur

Rai

Chatterjee³

et al. 2016

Pharmaceutical Biology

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“…Rb ginsenosides, such as Rb1, Rb2, Rc, Rd metabolites, are (20) S protopanaxadiol derivatives, while the Rg group, such as Rg1 and Re metabolites, have (20) S protopanaxatriol as a sapogenin (Biswas et al 2017). Many pharmacological investigations (Christensen 2009;Tung et al 2012; indicate that ginsenosides are responsible for the adaptogenic, antidiabetic, antitumor Pawar and Shivakumar 2012;Wang et al 2015), anti-obesity (Marrelli et al 2016) and neuroprotective (Radad et al 2011) properties of ginseng.…”

Section: Introductionmentioning

confidence: 99%

The content of triterpene saponins and phenolic compounds in American ginseng hairy root extracts and their antioxidant and cytotoxic properties

Kochan

Szymańska

Wielanek

et al. 2019

Plant Cell Tiss Organ Cult

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Panax quinquefolium is a perennial herb of the Araliaceae family native to North America. Its roots have been used in traditional and Chinese medicine. The aim of this study was to determine the phenolic profile of methanolic extracts of P. quinquefolium hairy roots cultivated in flasks and a bioreactor, as well as extracts from the roots of three-year-old field-grown plants. Additionally, the phenol and ginsenoside components of the tested extracts were identified by HPLC, and their antioxidant and cytotoxic properties were evaluated. The antioxidant effect was evaluated by FRAP (ferric reducing antioxidant power), and ABTS ([2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation scavenging tests, and their effect on the viability of the glioblastoma cell (T98G) line was measured using the 3-(4,5-dimethylthazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The LC-MS/MS analysis revealed the presence of 16 phenolic compounds identified as phenolic acids (ten compounds) or flavonoids (six compounds). The highest phenol content was observed in the transformed roots of flask-grown P. quinquefolium (1.6 mg g −1 d.w.), followed by these grown in the bioreactor (1.1 mg g −1 d.w.). However, the highest ginsenoside content was found in the roots of the naturally-cultivated plants (67.6 mg g −1 d.w.). The methanolic extracts from hairy root culture of P. quinquefolium appear to have significant antioxidant and cytotoxic potential. Such transformed American ginseng root cultures could represent a potential source of bioactive metabolites for the food or pharmaceutical industry. Key message First time phenolic compound level, antioxidant and cytotoxic properties were estimated in hairy root cultures of Panax quinquefolium cultivated in flasks and nutrient sprinkle bioreactor. Ginsenosides content was also determined.

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“…16 Consequently, at present, diverse combinations of behavioral and other models usually used for discovering and developing psychoactive drugs are now commonly used for predicting or estimating their therapeutic potentials as adaptogenic herbs and their bioactive constituents. 17,18 …”

Section: Introductionmentioning

confidence: 99%

Adaptogenic potential of andrographolide: An active principle of the king of bitters (Andrographis paniculata)

Thakur

Chatterjee²,

Kumar

2015

Journal of Traditional and Complementary Medicine

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Andrographolide is a major bioactive secondary plant metabolite isolated Andrographis paniculata (Burm. F.) Wall. Ex. Nees. (穿心蓮 chuān xīn lián), a well-known traditionally used medicinal herb. The aim of the study was to pharmacologically evaluate the beneficial effect of andrographolide on stress-induced thermoregulatory and other physiological responses in mice. A stress-induced hyperthermia test was conducted in mice. The test agents were orally administered once daily for 11 consecutive days, and treatment effects on body weight changes, basal rectal temperature, and foot-shock-triggered hyperthermic responses were quantified on Day 1, Day 5, Day 7, and Day 10 of the experiments. Pentobarbital-induced hypnosis was quantified on the 11th day of treatment. Observations made during a pilot dose finding experiment revealed that, like A. paniculata extracts, pure andrographolide also possess adaptogenic properties. Observed dose-dependent efficacies of 3 mg/kg/d, 10 mg/kg/d, and 30 mg/kg/d andrographolide in the pilot experiment were reconfirmed by conducting two further analogous experiments using separate groups of either male or female mice. In these confirmatory experiments, efficacies of andrographolide were compared with that of 5 mg/kg/d oral doses of the standard anxiolytic diazepam. Significantly reduced body weights and elevated core temperatures of the three vehicle-treated control groups observed on the 5th day and subsequent observational days were completely absent even in the groups treated with the lowest andrographolide dose (3 mg/kg/d) or diazepam (5 mg/kg/d). Benzodiazepine-like potentiation of pentobarbital hypnosis was observed in andrographolide-treated animals. These observations reveal that andrographolide is functionally a diazepam-like desensitizer of biological mechanisms, and processes involved in stress trigger thermoregulatory and other physiological responses.

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A current status of adaptogens: natural remedy to stress

Cited by 31 publications

References 36 publications

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

The content of triterpene saponins and phenolic compounds in American ginseng hairy root extracts and their antioxidant and cytotoxic properties

Adaptogenic potential of andrographolide: An active principle of the king of bitters (Andrographis paniculata)

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