A Curious Case of Plasma Cell Gingivitis

Mukherjee, Manali; Katarkar, Ashish; Bandyopadhyay, Paritosh; Chaudhuri, Kripasindhu

doi:10.17659/01.2015.0127

Cited by 2 publications

(5 citation statements)

References 12 publications

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“…[ 24 25 ] Radiographic finding of generalized horizontal bone loss was seen in a single case as mentioned in the literature. [ 15 ] Silverman has described syndromic association with the triad of PCG, glossitis, and cheilitis but no case in our series showed this association. [ 26 ] Three cases in the literature were associated with supraglottic lesions but none of our present cases showed laryngeal lesions.…”

Section: Discussionmentioning

confidence: 67%

“…The published literature showed 43 reported cases of PCG from 1971 to 2020 [ Supplementary Table 1 ]. [ 1 4 5 6 7 9 11 15 16 17 18 19 20 21 22 23 24 25 27 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 ]…”

Section: Resultsmentioning

confidence: 99%

“…[ 3 ] Immunonegativity to CD117, CD56, low to negative Ki67proliferation index, and equivocal reactivity for kappa and lambda in all the present cases of PCG was in accordance with Mukherjee et al . [ 15 ] However, CD56 was evaluated for the first time in PCG. The results were in agreement with the published data which showed CD56 immunonegativity in normal plasma cells.…”

Section: Discussionmentioning

confidence: 99%

“…studied the expression of CD44, CD34, CD43, Ki67, and CD117 in addition to kappa lambda profile in discrimination of PCG from malignancies. [ 15 ] However CD56 expression is not yet studied in PCG.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and immunohistochemical analysis of plasma cell gingivitis- A retrospective study

Mishra

Gupta

Kaur

et al. 2022

J Indian Soc Periodontol

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Background: This study aims to describe the demographics and clinicopathological characteristics of the cases of plasma cell gingivitis (PCG) reported in our institute, supported by a review of pertinent literature. Further, we investigated the role of the cluster of differentiation CD138, Ki67, CD56, and CD117 immunoexpression in the differential diagnosis of PCG from plasma cell dyscrasias. Materials and Methods: All histopathologically confirmed cases of PCG, whose relevant details could be obtained, were included in this study. They were subjected to panel of immunohistochemical markers to exclude plasma cell malignancies. Further, published English literature for PCG since 1970–2020 was reviewed. Results: Nine histopathologically confirmed cases of PCG, were retrieved from the archives of our department. The cases comprised 3 males and 6 females with their ages ranging between 14 and 82 years. The plasma cells exhibited equivocal reactivity for kappa and lambda; and immunonegativity for CD56, CD117 with low Ki67 proliferation index. Published literature in English showed 43 cases of PCG were predominantly female; the diffuse involvement of maxilla and mandible was a common finding. Conclusion: In addition to kappa lambda reactivity, an immunoprofile of CD138, Ki67, CD56, and CD117 may be used as a diagnostic adjunct to exclude malignant plasma cell lesions in confusing cases.

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Section: Discussionmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and immunohistochemical analysis of plasma cell gingivitis- A retrospective study

Mishra

Gupta

Kaur

et al. 2022

J Indian Soc Periodontol

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“…Plasma cell gingivitis is a rare benign condition of the gingiva characterized by sharply demarcated erythematous and edematous gingivitis often extending to the mucogingival junction [1] . Other terminologies previously used for this unusual type of conditioned enlargement were atypical gingivitis, allergic gingivitis, plasmacytosis of the gingiva, plasma cell gingivostomatitis and idiopathic gingivostomatitis [2] . Plasma cell gingivitis is considered a hypersensitive reaction to some antigen, often to chewing gum, toothpaste, and other foreign substances.…”

Section: Introductionmentioning

confidence: 99%

Atypical gingivitis: A rare case report of recurrent and familial history, and its surgical management

Jeyachandran¹,

Modi²,

Shetty³

2021

Int. J. Appl. Dent. Sci.

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Plasma cell gingivitis, an infrequent benign entity, is an inflammatory or reactive condition of the gingiva to certain allergens or to an unknown factor. It is clinically characterized by erythematous, edematous, granular/cobblestone appearance of gingival surfaces with clear demarcation from the mucogingival junction. It easily bleeds on manipulation and may be associated with a burning sensation to spicy food consumption. As the name suggests it is diffuse and massive infiltration of plasma cells into the subepithelial gingival tissue. It is a hypersensitivity reaction to some antigen, often flavouring agents or spices found in chewing gums, toothpastes and lorenzes. Plasma cell gingivitis is also known as atypical gingivostomatitis, allergic gingivostomatitis, unusual gingivostomatitis and idiopathic gingivostomatitis. Histologically, the lesion shows dense plasma cell infiltrate of the connective tissue. We report a case of a rarely seen mucosal pathology of a 51 yr old male patient with a chief complaint of bleeding swollen mass in the upper and lower front tooth region who presented with this rare condition and its histological diagnosis and its management.

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A Curious Case of Plasma Cell Gingivitis

Cited by 2 publications

References 12 publications

Clinicopathological and immunohistochemical analysis of plasma cell gingivitis- A retrospective study

Clinicopathological and immunohistochemical analysis of plasma cell gingivitis- A retrospective study

Atypical gingivitis: A rare case report of recurrent and familial history, and its surgical management

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