A curable pseudo-dementia related to an atypical presentation of giant cell arteritis

Lahaye, Clément; Sanchez, M.J.; Rouet, Audrey; Gross, A; Faucher, Nathalie; Raynaud-Simon, A.; Lilamand, Matthieu

doi:10.1093/ageing/afaa010

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…9,39 Cognitive dysfunction has been shown in headaches attributed to genetic vasculopathies, arteritides, posterior reversible encephalopathy syndrome, reversible cerebral vasoconstrictive syndrome, sickle cell disease, concussion, and idiopathic intracranial hypertension. [40][41][42][43][44][45] Cognitive dysfunction is observed during the attack in 28-77% of patients with secondary headaches. 14 In our study, cognitive dysfunction was detected during the attack in 50% of patients with cervicogenic headache, a fugure comparable to that found in literature for secondary hadaches.…”

Section: Discussionmentioning

confidence: 99%

Frequency of cognitive dysfunction in individuals with cervicogenic headache

Karpuz,

YILMAZ,

AKDERE

et al. 2023

NeuroAsia

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Background: Both primary and secondary headaches have been associated with cognitive dysfunction and depression. Objective: This study aims to investigate the effects of cervicogenic headache on cognitive function, quality of life and mood. Methods: This single-center, cross-sectional comparative study includes 30 patients diagnosed with cervicogenic headache by a neurologist and 30 healthy controls. The pain level of the participants was evaluated with the Visual Analog Scale (VAS), their mood with the Beck Depression Inventory (BDI) and the Pain Catastrophizing Scale, their quality of life with the Short Form-36 (SF-36), and their cognitive status by a psychologist with the Standard Mini Mental Test (SMMT) and Montreal Cognitive Assessment Scale (MoCA). Results: All MoCA domains except for orientation and the SMMT scores were significantly lower in the cervicogenic headache group compared to the control group (p< 0,05). In addition, scores for the pain catastrophizing scale and selected SF-36 sub-parameters (physical function, physical role difficulty, social functionality, pain and general health perception) were significantly lower in the cervicogenic headache group (p< 0,05). The Beck Depression Inventory score was significantly higher in patients with cervicogenic headache than in the control group (p=0.018). Conclusion: Patients with cervicogenic headache exhibit worse cognitive performance during their headache. Additionally, compared to healthy controls, they had higher rates of depression and pain catastrophizing as well as a lower quality of life.

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Section: Discussionmentioning

confidence: 99%

Frequency of cognitive dysfunction in individuals with cervicogenic headache

Karpuz,

YILMAZ,

AKDERE

et al. 2023

NeuroAsia

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“…In addition, the evidence is accumulating that other forms of neurological disorders, such as dementia and neurodegenerative disorders, can be initial or coexistent manifestations of GCA ( Pascuzzi et al, 1989 ; Caselli, 1990 ; Caselli and Hunder, 1993 ; Ely, 1998 ; Incalzi et al, 2005 ; Alisky, 2008 ; Solans-Laqué et al, 2008 ; Kushida et al, 2011 ; Lahaye et al, 2020 ). It is noteworthy that some of these cases showed improvement after GCA treatment, indicating that GCA could manifest as a “treatable” neurological disorder.…”

Section: Neurological Aging and Giant Cell Arteritismentioning

confidence: 99%

Aging-Related Vascular Inflammation: Giant Cell Arteritis and Neurological Disorders

Watanabe¹,

Hashimoto²

2022

Front. Aging Neurosci.

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Aging is characterized by the functional decline of the immune system and constitutes the primary risk factor for infectious diseases, cardiovascular disorders, cancer, and neurodegenerative disorders. Blood vessels are immune-privileged sites and consist of endothelial cells, vascular smooth muscle cells, macrophages, dendritic cells, fibroblasts, and pericytes, among others. Aging also termed senescence inevitably affects blood vessels, making them vulnerable to inflammation. Atherosclerosis causes low-grade inflammation from the endothelial side; whereas giant cell arteritis (GCA) causes intense inflammation from the adventitial side. GCA is the most common autoimmune vasculitis in the elderly characterized by the formation of granulomas composed of T cells and macrophages in medium- and large-sized vessels. Recent studies explored the pathophysiology of GCA at unprecedented resolutions, and shed new light on cellular signaling pathways and metabolic fitness in wall-destructive T cells and macrophages. Moreover, recent reports have revealed that not only can cerebrovascular disorders, such as stroke and ischemic optic neuropathy, be initial or coexistent manifestations of GCA, but the same is true for dementia and neurodegenerative disorders. In this review, we first outline how aging affects vascular homeostasis. Subsequently, we review the updated pathophysiology of GCA and explain the similarities and differences between vascular aging and GCA. Then, we introduce the possible link between T cell aging, neurological aging, and GCA. Finally, we discuss therapeutic strategies targeting both senescence and vascular inflammation.

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“…A hypothesis is that the cognitive changes are thought to be due to thalamic and inferomesial temporal lobe infarcts [95,97]. Patients can have abrupt confusion during active giant cell arteritis episodes and might progress to a more chronic dementia [95][96][97][98][99].…”

Section: Giant Cell Arteritismentioning

confidence: 99%

Cognitive Impairment in Primary and Secondary Headache Disorders

Dhaem

Robbins

2022

Curr Pain Headache Rep

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Purpose of ReviewTo critically evaluate the recent literature on cognitive impairment and headache. Recent Findings Neurocognitive symptoms are prevalent, debilitating, and occur often with both primary and secondary headache disorders. Summary This is a "narrative review of the current literature in PubMed on cognitive function and headache." Migraine is associated with cognitive impairment years before a migraine diagnosis. In young and middle-aged adults, migraine is associated with deficits in attention, executive function, processing speed, and memory. It is unlikely that migraine is associated with dementia. Although methodologically difficult to assess, there does not seem to be an association between tension-type headache and cognitive dysfunction. In early to midlife, cluster headache seems to be associated with executive dysfunction. Several secondary headache syndromes relevant to clinicians managing headache disorders are associated with poorer cognitive performance or distinctive cognitive patterns, including those attributed to chronic cerebral or systemic vascular disorders, trauma, and derangements of intracranial pressure and volume, including frontotemporal brain sagging syndrome.

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A curable pseudo-dementia related to an atypical presentation of giant cell arteritis

Cited by 4 publications

References 5 publications

Frequency of cognitive dysfunction in individuals with cervicogenic headache

Frequency of cognitive dysfunction in individuals with cervicogenic headache

Aging-Related Vascular Inflammation: Giant Cell Arteritis and Neurological Disorders

Cognitive Impairment in Primary and Secondary Headache Disorders

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