“…The JH signaling that activates the imaginal development in cockroaches, that is, MEKRE93 pathway (Met-Krh1-E93), could work as a regulator of caste differentiation in termites (Korb & Belles, 2017). The knockdown of Krh1, however, did not affect the soldier differentiation in Z. nevadensis, suggesting that E93 cannot be downstream of Met at least during presoldier molt of this species (Masuoka, Toga, Nalepa, & Maekawa, 2018). Indeed, expression analyses on some JH pathway genes between queens and workers in three termite species with genome information (Z. nevadensis, Cryptotermes secundus, and Macrotermes natalensis), suggested that the JH signaling would be diversified among termite lineages, especially between lower (the first two) and higher (the third) termites (Jongepier et al, 2018).…”