A cross-talk EGFR/VEGFR-targeted bispecific nanoprobe for magnetic resonance/near-infrared fluorescence imaging of colorectal cancer

Wang, Qian; Zhao, Xinming; H, Yan; Kang, Feiyu; Qiao, Yanyan; Li, Dan; Li, Zhangfu

doi:10.1557/mrc.2018.127

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Compared with other metal nanomaterials [20][21][22][23], Fe 3 O 4 -NPs are one of the few FDA-approved nanomaterials for clinical use, which has simple preparation [24][25][26], safe and stable chemical properties, and good biocompatibility [27][28][29]. Moreover, it has been widely used in pathogen detection [30][31][32][33][34], tumor diagnosis and treatment [35][36][37], gene mutation analysis [38][39][40][41][42], targeted drug delivery [43][44][45], and nuclear magnetic resonance imaging (MRI) [46][47][48]. In addition, recent studies have shown that Fe 3 O 4 -NPs, due to their rich Fe 2+ and Fe 3+ contents, can affect the iron metabolism of tumor cells, increase local ROS levels in tumor tissues, participate in or even induce the occurrence of ferroptosis in tumor cells, and then be able to inhibit or kill tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Progress in the Mechanism of the Effect of Fe3O4 Nanomaterials on Ferroptosis in Tumor Cells

Wang

Bao

et al. 2023

Molecules

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Ferroptosis is a new form of iron-dependent programmed cell death discovered in recent years, which is caused by the accumulation of lipid peroxidation (LPO) and reactive oxygen species (ROS). Recent studies have shown that cellular ferroptosis is closely related to tumor progression, and the induction of ferroptosis is a new means to inhibit tumor growth. Biocompatible Fe3O4 nanoparticles (Fe3O4-NPs), rich in Fe2+ and Fe3+, act as a supplier of iron ions, which not only promote ROS production but also participate in iron metabolism, thus affecting cellular ferroptosis. In addition, Fe3O4-NPs combine with other techniques such as photodynamic therapy (PDT); heat stress and sonodynamic therapy (SDT) can further induce cellular ferroptosis effects, which then enhance the antitumor effects. In this paper, we present the research progress and the mechanism of Fe3O4-NPs to induce ferroptosis in tumor cells from the perspective of related genes and chemotherapeutic drugs, as well as PDT, heat stress, and SDT techniques.

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Section: Introductionmentioning

confidence: 99%

Progress in the Mechanism of the Effect of Fe3O4 Nanomaterials on Ferroptosis in Tumor Cells

Wang

Bao

et al. 2023

Molecules

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“…to the right place at the right time. Various delivery systems are designed to track the release and infiltration process of nanoparticles or drugs at the tumor site, guiding local treatment and monitoring the effects after treatment [2,3,4]. Due to low temporal or spatial resolution, the contemporary methods available are unable to track the kinetics of drugs or nanoparticles in vivo for a sustained period of time [5].…”

Section: Introductionmentioning

confidence: 99%

Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking In Vivo

Wang

et al. 2019

Materials

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Fluorescence imaging offers a new approach to visualize real-time details on a cellular level in vitro and in vivo without radioactive damage. Poor light stability of organic fluorescent dyes makes long-term imaging difficult. Due to their outstanding optical properties and unique structural features, graphene quantum dots (GQDs) are promising in the field of imaging for real-time tracking in vivo. At present, GQDs are mainly loaded on the surface of nanoparticles. In this study, we developed an efficient and convenient one-pot method to load GQDs into nanoparticles, leading to longer metabolic processes in blood and increased delivery of GQDs to tumors. Optical-magneto ferroferric oxide@polypyrrole (Fe3O4@PPy) core-shell nanoparticles were chosen for their potential use in cancer therapy. The in vivo results demonstrated that by loading GQDs, it was possible to monitor the distribution and metabolism of nanoparticles. This study provided new insights into the application of GQDs in long-term in vivo real-time tracking.

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Advances in Imaging Modalities and Contrast Agents for the Early Diagnosis of Colorectal Cancer

Zhu

Lui

et al. 2021

j biomed nanotechnol

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Colorectal cancer is one of the most common gastrointestinal cancers worldwide. The mortality rate of colorectal cancer has declined by more than 20% due to the rapid development of early diagnostic techniques and effective treatment. At present, there are many diagnostic modalities available for the evaluation of colorectal cancer, such as the carcinoembryonic antigen test, the fecal occult blood test, endoscopy, X-ray barium meal, computed tomography, magnetic resonance imaging, and radionuclide examination. Sensitive and specific imaging modalities have played an increasingly important role in the diagnosis of colorectal cancer following the rapid development of novel contrast agents. This review discusses the applications and challenges of different imaging techniques and contrast agents applied to detect colorectal cancer, for the purpose of the early diagnosis and treatment of patients with colorectal cancer.

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A cross-talk EGFR/VEGFR-targeted bispecific nanoprobe for magnetic resonance/near-infrared fluorescence imaging of colorectal cancer

Abstract: Abstract

Cited by 3 publications

References 30 publications

Progress in the Mechanism of the Effect of Fe3O4 Nanomaterials on Ferroptosis in Tumor Cells

Progress in the Mechanism of the Effect of Fe3O4 Nanomaterials on Ferroptosis in Tumor Cells

Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking In Vivo

Advances in Imaging Modalities and Contrast Agents for the Early Diagnosis of Colorectal Cancer

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