A cross‐sectional study on the prevalence of metabolic syndrome in psoriasis compared to psoriatic arthritis

Bostoen, Jessica; Praet, Liesbet Van; Brochez, Liève; Mielants, Herman; Lambert, Jo

doi:10.1111/jdv.12071

Cited by 33 publications

(32 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found no differences between patients with Ps and PsA for any of the variables being taken. Such studies have been reported on rare occasions and the results are similar to ours [47,48]. …”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Santos‐Juanes

Coto-Segura²,

Fernández‐Vega³

et al. 2015

Dermatology

View full text Add to dashboard Cite

Background: Psoriasis (Ps) has been associated with an increased incidence of cardiovascular disease. Interesting epidemiological evidence suggests associations between Ps and dyslipidemia (DL), a well-established risk factor for cardiovascular disease. Objective: This study aimed to investigate the association between Ps and multiple measurements of DL, which include levels of triglycerides (TGs), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and total cholesterol (TCh). We also studied the relationship between DL and disease duration. Methods: A prospective hospital-based study was conducted. A total of 661 Caucasian patients with chronic plaque Ps and 661 sex- and age-matched controls were enrolled. Results: Multivariate analysis showed that in psoriatic patients the odds ratio (OR) of TCh >200 mg/dl was 1.406 (95% confidence interval 1.115-1.173), the OR of LDL cholesterol >130 mg/dl was 1.375 (95% confidence interval 1.088-1.738), the OR of HDL cholesterol <40 mg/dl was 0.881 (95% confidence interval 0.599-1.297), and the OR of TGs >150 mg/dl was 1.041 (95% confidence interval 0.783-1.385). We did not find a relationship between lipid levels and disease duration. Conclusion: Based on our population Ps is associated with alterations in TCh and LDL cholesterol, but not in TGs and HDL cholesterol, when ATP III panel levels are used. These alterations are not related to disease duration.

show abstract

Section: Discussionsupporting

confidence: 80%

“…There was no relationship with disease severity (PASI), early/late disease onset (adjusted by age), presence of PsA or concomitant administration of systemic treatment [20,21,39,43,47]. We found no differences between patients with Ps and PsA for any of the variables being taken.…”

Section: Discussionmentioning

confidence: 37%

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Santos‐Juanes

Coto-Segura²,

Fernández‐Vega³

et al. 2015

Dermatology

View full text Add to dashboard Cite

show abstract

“…Table 1 lists the characteristics of the study population, which showed no significant difference in gender, age, disease duration and age of onset, and cardiovascular profile. The study population had previously been described where we found that the prevalence of MetS was significantly higher in the PsO group, supposedly due to significant difference in abdominal obesity between both groups and remained significant in a multivariate-adjusted model including age, disease severity, disease duration, systemic therapy or systemic inflammation (P = 0.002) (5). The prevalence of CVD was not significantly different between PsO and PsA patients.…”

Section: Resultsmentioning

confidence: 96%

“…Moreover, psoriasis (PsO), an immune-mediated inflammatory disease (IMID), may coexist with other IMIDs such as psoriatic arthritis (PsA), Crohn's disease, rheumatoid arthritis and ankylosing spondylitis (3,4). In addition, we showed that the risk for metabolic syndrome (MetS) is higher in patients with PsO compared with patients with PsA (5). Timely detection of these comorbidities is of crucial importance as they can greatly reduce the life expectancy of these patients.…”

Section: Background and Questions Addressedmentioning

confidence: 96%

Analysis of telomere length as predictive marker in psoriasis for comorbidities

Coussens

Grine

Bostoen

et al. 2016

Experimental Dermatology

View full text Add to dashboard Cite

“…Одним из ча-стых коморбидных состояний псориаза является метаболический синдром (МС) [8,14,16,18,22].…”

unclassified

Особенности Композиции Тела И Уровня Лептина Крови У Больных Псориазом С Метаболическим Синдромом

Донцова¹

2018

Курск. науч.-практ. вестн. «Человек и его здоровье»

View full text Add to dashboard Cite

Обследованы 432 больных вульгарным псориазом, мужчин -213 (49.3%), женщин -219 (50.7%). В зависимости от величины индекса PASI больные были разделены на две группы: с ограниченной формой (PASI -9.6±0,01 балла, n=60) и с распространенной формой заболевания (PASI -49.53±0.46 балла, n=372). 312 больных с распространенной формой псориаза имели признаки метаболического синдрома (МС) и составили основную группу, другая часть паци-ентов с распространенной формой заболевания, не имеющих признаков МС, -группу сравнения (n=60). У обследо-ванных пациентов проведено антропометрическое исследование и определение уровня лептина в крови. Показана ста-тистически значимая связь между распространенностью кожного процесса, уровнем лептина крови и присутствием МС, что свидетельствует о патогенетической роли метаболических нарушений при псориазе.Ключевые слова: псориаз, метаболический синдром, индекс массы тела, абдоминальное ожирение, лептин крови. PECULIARITIES OF BODY COMPOSITION AND LEPTIN LEVEL IN PATIENTS WITH PSORIASIS WITH METABOLIC SYNDROME Dontsova E.V. Department of Dermatovenereology of Voronezh State Medical University named after N.N. Burdenko, Voronezh432 patients (213 men (49.3%) and 219 women (50.7%)) with vulgar psoriasis were examined. Depending on the size of the PASI index, the patients were divided into two groups: with a limited form (PASI -9.6±0.01, n = 60) and with a common form of the disease (PASI -49.53±0.46, n = 372). 312 patients with a common form of psoriasis had signs of metabolic syndrome (MS) and made up the main group, another part of patients (n = 60) with a common form of the disease, without signs of MS -comparison group. Anthropometric examination and determination of leptin level in blood were carried out in the examined patients. A statistically significant relationship between the prevalence of the skin process, the level of blood leptin and the presence of MS is shown, which indicates the pathogenetic role of metabolic disturbances in psoriasis.

show abstract

A cross‐sectional study on the prevalence of metabolic syndrome in psoriasis compared to psoriatic arthritis

Abstract: Metabolic syndrome is more prevalent in patients with PsO than in PsA patients, mainly determined by the higher prevalence of abdominal obesity in PsO compared with PsA group.

Cited by 33 publications

References 20 publications

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Analysis of telomere length as predictive marker in psoriasis for comorbidities

Особенности Композиции Тела И Уровня Лептина Крови У Больных Псориазом С Метаболическим Синдромом

Contact Info

Product

Resources

About