Analysis of telomere length as predictive marker in psoriasis for comorbidities

Coussens, Emma; Grine, Lynda; Bostoen, Jessica; Mielants, Herman; Lambert, Jo

doi:10.1111/exd.12959

Cited by 4 publications

(4 citation statements)

References 9 publications

(9 reference statements)

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“…Therefore, the length of the telomere is viewed as a "molecular clock" for biological aging. During recent decades, a close association between LTL and IMIDs has been reported (Steer et al, 2007;Tamayo et al, 2010;Coussens et al, 2016;Fessler et al, 2016;Newton et al, 2019), indicating the underlying involvement of TL in pathogenesis of IMIDs. A noticeable difference in the alteration of TL in IMID patients when compared to controls has been suggested by recent studies, which have shown mixed results.…”

Section: Introductionmentioning

confidence: 95%

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

et al. 2023

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Objective: To elucidate the potential causality of leukocyte telomere length (LTL) with immune-mediated inflammatory diseases (IMIDs), we conducted a Mendelian randomization (MR) study.Methods: The genetically predicted causation between LTL and IMIDs was evaluated using a two-sample MR method. We analyzed 16 major IMIDs, which included systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), ulcerative colitis (UC), Crohn’s disease (CD), ankylosing spondylitis (AS), sicca syndrome (SS), rheumatoid arthritis (RA), type 1 diabetes (T1D), primary sclerosing cholangitis (PSC), idiopathic pulmonary fibrosis (IPF), atopic dermatitis (AD), sarcoidosis, hypothyroidism, hyperthyroidism, psoriasis, and childhood asthma. The random-effects inverse-variance weighted (IVW) method was performed as the main analytical approach in MR. Various sensitivity analyses, including MR-Egger, MR robust adjusted profile score (MR-RAPS), weighted median, MR pleiotropy residual sum and outlier (MR-PRESSO) methods, weighted mode, radial plot, and radial regression, were used to guarantee the robustness of the results and detect horizontal pleiotropy. Cochran’s Q value was calculated to check for heterogeneity, and the MR Steiger approach was used to test the causal direction.Results: The MR results indicated significant inverse associations of LTL with risks of psoriasis (OR: 0.77, 95% CI: 0.66–0.89, and p = 3.66 × 10−4), SS (OR: 0.75, CI: 0.58–0.98, and p = 0.03), RA (OR: 0.77, 95% CI: 0.68–0.88, and p = 9.85 × 10−5), hypothyroidism (OR: 0.84, 95% CI: 0.78–0.91, and p = 7,08 × 10−6), hyperthyroidism (OR: 0.60, 95% CI: 0.44–0.83, and p = 1.90 × 10−3), sarcoidosis (OR: 0.67, 95% CI: 0.54–0.83, and p = 2.60 × 10−4), and IPF (OR: 0.41, 95% CI: 0.29–0.58, and p = 4.11 × 10−7) in the FinnGen study. We observed that longer LTL was associated with an increased risk of AS susceptibility (OR: 1.51, 95% CI: 1.18–1.94, and p = 9.66 × 10−4). The results of the IVW method showed no causal relationship between TL and SLE (OR: 0.92, 95% CI: 0.62–1.38, and p = 0.69) in the FinnGen study; however, a significantly positive correlation was shown between LTL and SLE in another larger GWAS (OR: 1.87, 95% CI: 1.37–2.54, and p = 8.01 × 10−5).Conclusion: Our findings reveal that abnormal LTL has the potential to increase the risk of IMIDs. Therefore, it could be treated as a predictor and may provide new potential treatment targets for IMIDs. However, the change of LTL may not be the direct cause of IMIDs. Further studies should aim at the pathogenic mechanism or potential protective effects of LTL in IMIDs.

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Section: Introductionmentioning

confidence: 95%

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

et al. 2023

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“…Accordingly, Liu et al not only confirmed the above results in psoriatic patients but they also observed an association between telomerase activity and disease severity but not duration [ 122 ]. On the other hand, when telomere length was analyzed as a possible predictive marker, it failed to show any association with the development of metabolic syndrome or cardiovascular disease in psoriatic patients [ 123 ].…”

Section: The Telomere/telomerase System In Chronic Disorders Is Imentioning

confidence: 99%

The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?

Kordinas

Ioannidis

Chatzipanagiotou

2016

Genes

116

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Telomeres are specialized nucleoprotein structures located at the end of linear chromosomes and telomerase is the enzyme responsible for telomere elongation. Telomerase activity is a key component of many cancer cells responsible for rapid cell division but it has also been found by many laboratories around the world that telomere/telomerase biology is dysfunctional in many other chronic conditions as well. These conditions are characterized by chronic inflammation, a situation mostly overlooked by physicians regarding patient treatment. Among others, these conditions include diabetes, renal failure, chronic obstructive pulmonary disease, etc. Since researchers have in many cases identified the association between telomerase and inflammation but there are still many missing links regarding this correlation, the latest findings about this phenomenon will be discussed by reviewing the literature. Our focus will be describing telomere/telomerase status in chronic diseases under the prism of inflammation, reporting molecular findings where available and proposing possible future approaches.

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“…In this subgroup, the authors found significantly longer telomeres in the patients without MetS compared to the appropriate controls; despite that, no association of telomere length with the development of MetS or cardiovascular diseases in psoriasis was previously published. 29 …”

Section: Discussionmentioning

confidence: 99%

Telomere length, oxidative and epigenetic changes in blood DNA of patients with exacerbated psoriasis vulgaris

Beránek

Borský

Fiala

et al. 2023

Anais Brasileiros de Dermatologia

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Analysis of telomere length as predictive marker in psoriasis for comorbidities

Cited by 4 publications

References 9 publications

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study

The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?

Telomere length, oxidative and epigenetic changes in blood DNA of patients with exacerbated psoriasis vulgaris

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