A cross-sectional study of untreated depression and anxiety in cutaneous lupus erythematosus and dermatomyositis

Achtman, Jordan C.; Kling, Mitchel A.; Feng, Rui; Okawa, Joyce; Werth, Victoria P.

doi:10.1016/j.jaad.2015.09.016

Cited by 35 publications

(44 citation statements)

References 5 publications

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“…Our review demonstrates an overall prevalence of anxiety in psoriasis higher than the global population estimate of 7.3%, but comparable to a prevalence of depression of 12–28% in patients with psoriasis . Our prevalence estimates are comparable to rates of 28.6% and 39.0% reported in patients with systemic lupus erythematous and dermatomyositis respectively …”

Section: Discussionsupporting

confidence: 72%

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The prevalence of anxiety in patients with psoriasis: a systematic review of observational studies and clinical trials

Fleming

Bai

Pratt

et al. 2016

Acad Dermatol Venereol

114

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Psoriasis and anxiety are chronic conditions with significant morbidity and there is evidence that they may exacerbate one another. There is little data on the prevalence of anxiety in psoriasis and the effect of psoriasis treatment on comorbid anxiety. The objective of this study was to perform a systematic review of the literature to describe the prevalence and severity of clinical anxiety disorders or anxiety symptoms among adult patients with psoriasis and characterize the effect of anti-psoriatic interventions on clinical anxiety disorders or anxiety symptoms. We searched PubMed, EMBASE, and the Cochrane Database using search terms 'psoriasis' and 'anxiety'. Results were tabulated and verified by two independent reviewers. Meta-analyses were not performed due to heterogeneity of data. Of 213 publications identified, 938 194 patients from 15 papers were included. The mean age ranged from 31.9-59.4 years old, with a mean PASI score of 7.65-22.8 (reported by nine studies) and a body surface area involvement of 25.9-39.8% (reported by two studies). The prevalence of anxiety in patients with psoriasis was 7-48%, which was significantly higher than healthy controls in two of three studies (HR 1.29-1.31, P = 0.001 and OR 2.91 [95% CI, 2.01-4.21], P < 0.001). Four of five studies (n = 2029) demonstrated an improvement in anxiety symptoms with psoriasis treatment. This review demonstrates a high prevalence of anxiety of adult patients with psoriasis suggesting that patients would benefit from systematic screening. Although the data suggest that anxiety may be improved through various psoriasis treatments, larger prospective randomized trials are needed to confirm this effect.

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Section: Discussionsupporting

confidence: 72%

“…6 Our prevalence estimates are comparable to rates of 28.6% and 39.0% reported in patients with systemic lupus erythematous and dermatomyositis respectively. 34…”

Section: Relative Burden Of Anxiety In Psoriasismentioning

confidence: 99%

The prevalence of anxiety in patients with psoriasis: a systematic review of observational studies and clinical trials

Fleming

Bai

Pratt

et al. 2016

Acad Dermatol Venereol

114

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“…In a case-control study conducted by Jalenques et al, it was found that the most frequently observed current psychiatric disorders were major depressive disease (39%) and anxiety disorders (35%) in patients with skin-restricted lupus [28]. In another cross-sectional study, 34.7% of the patients with DLE met the criteria for depression and/or anxiety with need of mental health care or psychotropic treatment [29]. Skin atrophy, scarring, and scarring alopecia may cause mood and anxiety disorders and can seriously impact the quality of life in patients with DLE.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study

Akarsu

Özbağçıvan

Semiz

et al. 2017

Journal of Immunology Research

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Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. This was a cross-sectional, case-control study, including 60 patients with DLE and 82 age- and gender-matched control subjects. In DLE group, the presence of MetS was observed as more frequent (48.3% versus 24.4%, p = 0.003), and hypertriglyceridemia (43.3% versus 22.0%, p = 0.006) and reduced HDL-cholesterol (61.7% versus 23.2%, p < 0.001) among the MetS components were found significantly higher when compared to the control group. DLE patients with MetS were at older age (50.45 ± 11.49 versus 43.06 ± 12.09, p = 0.02), and hypertension, hyperlipidemia/dyslipidemia, and cardiovascular disease histories were observed at a higher ratio when compared to the patients without MetS. Between the DLE patients with and without MetS, no significant difference was observed in terms of clinical characteristics of DLE. Moreover, further large case-control studies with follow-up periods would be required to clearly assess the impact of MetS on the clinical outcomes of DLE.

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“…IIMs are severe and potentially life-threatening conditions that are associated with significant non-lethal morbidity. Depression 11 and sexual dysfunction 12 are not uncommon. In a study that included 1715 patients with IIMs, health-related quality of life was found to be significantly reduced compared with general patients and patients with rheumatoid arthritis.…”

Section: Non-lethal Morbiditymentioning

confidence: 99%

Management of the idiopathic inflammatory myopathies

Nadin¹,

Haque²,

Akil³

et al. 2019

Prescriber

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A cross-sectional study of untreated depression and anxiety in cutaneous lupus erythematosus and dermatomyositis

Cited by 35 publications

References 5 publications

The prevalence of anxiety in patients with psoriasis: a systematic review of observational studies and clinical trials

The prevalence of anxiety in patients with psoriasis: a systematic review of observational studies and clinical trials

High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study

Management of the idiopathic inflammatory myopathies

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