A cross-sectional study of the genital duct and renal anomalies in Egyptian cases of congenital absence of the vas deferens

AbdElnaser, Taha; Elkhiat, Yasser; El-Azizi, Hatem; Fatah, El; Abd, Mohamed; Elshibany, Ahmed Mahmoud; Din, Sameh Fayek GamalEl

doi:10.1080/14647273.2021.1918352

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…Furthermore, 32 studies were excluded because they were review articles or animal studies. Eventually, a total of 41 studies were included in this meta‐analysis 18–57 . According to the PRISMA guidelines, an overall data collection process is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…The results of a total of 20 studies were evaluated in this category. 18,[20][21][22]24,[26][27][28][32][33][34][35]37,40,43,52,[54][55][56][57] Left RA was found in 51.56% (95% CI: 44.79%-58.31%) out of a total of 1182 subjects and right RA had a prevalence of 43.19% (95% CI: 36.65%-49.84%) in 1182 patients. More information is provided in Table 5.…”

Section: Occurrence Of the Ra Sidementioning

confidence: 99%

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Renal agenesis: A meta‐analysis of its prevalence and clinical characteristics based on 15 641 184 patients

et al. 2023

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Our objective was to analyse the newest relevant data on worldwide prevalence and associated symptoms of renal agenesis (RA). This meta‐analysis builds on previous systematic reviews to include bilateral RA, its symptoms and data on gender, unilateral RA and anomaly location prevalence. Review of available data included records in English and other languages from PubMed, Embase, ScienceDirect, Web of Science, SciELO, BIOSIS, Current Content Connect Korean Journal Database and Russian Citation Index and Google. A total of 15 641 184 patients were analysed in relation to the prevalence of RA. The pooled prevalence of RA was 0.03% (95% CI: 0.03%–0.04%). Based on 500 subjects, a pooled prevalence of 47.96% (95% CI: 31.55%–64.58%) for unilateral and 52.04% (95% CI: 35.42%–68.45%) for bilateral RA has been set. Our study presents the newest generalized findings on bilateral RA. There appears to be universal disease and symptom prevalence with minor differences between world regions, although quality of future observational research should include genomic data. This will provide even further insight into the prognosis of various renal anomalies and their etiologies.

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Section: Resultsmentioning

confidence: 99%

Section: Occurrence Of the Ra Sidementioning

confidence: 99%

Renal agenesis: A meta‐analysis of its prevalence and clinical characteristics based on 15 641 184 patients

et al. 2023

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“…Strong evidence of the absence of the vas deferens in CBAVD patients relies on imaging examination. Although the aim of the physical examination of scrotum can by met (AbdElnaser et al, 2021), for those with residual vas deferens or fibrous cord-like structures remaining after vas deferens atresia, the diagnosis of CBAVD is often missed. Imaging examination can address this limitation.…”

Section: Imaging Examinationmentioning

confidence: 99%

Congenital Bilateral Absence of the Vas Deferens

Cai

2022

Front. Genet.

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Congenital bilateral absence of the vas deferens (CBAVD) is clinically characterized by the absence of the bilateral vas deferens; the main clinical manifestation is infertility, accounting for 1–2% of male infertility cases. CBAVD may be accompanied by congenital abnormalities in the urogenital system and cystic fibrosis (CF)-related clinical manifestations. CBAVD can develop as a mild manifestation of CF or can be isolated. The main pathogenic mechanism of CBAVD is gene mutation, and CBAVD and CF have a common genetic mutation background. CFTR mutation is the main pathogenic cause of CBAVD and CF, and ADGRG2 mutation is the second most common cause. Although lack of the vas deferens in CBAVD patients causes infertility due to the inability to release sperm, the testes of CBAVD patients have spermatogenic function. Therefore, CBAVD patients can achieve fertility through sperm retrieval surgery and assisted reproductive technology (ART). However, gene mutations in CBAVD patients can have an impact on the ART outcome, and there is a risk of passing on gene mutations to offspring. For CBAVD patients and their spouses, performing genetic counseling (which currently refers mainly to CFTR mutation screening) helps to reduce the risks of genetic mutations being passed on to offspring and of offspring having CF with concomitant CBAVD.

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A cross-sectional study of the genital duct and renal anomalies in Egyptian cases of congenital absence of the vas deferens

Cited by 2 publications

References 18 publications

Renal agenesis: A meta‐analysis of its prevalence and clinical characteristics based on 15 641 184 patients

Renal agenesis: A meta‐analysis of its prevalence and clinical characteristics based on 15 641 184 patients

Congenital Bilateral Absence of the Vas Deferens

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