A Cross-sectional Study of Intima-Media Thickness, Ethnicity, Metabolic Syndrome, and Cardiovascular Risk in 2268 Study Participants

Adolphe, Allen; Cook, Linda S.; Huang, Xun

doi:10.4065/84.3.221

Cited by 34 publications

(26 citation statements)

References 49 publications

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“…Insulin resistance, hyperglycemia, and diabetes are predictors of cardiovascular events, as is the presence of the metabolic syndrome (13-16, 24, 25). Men with metabolic syndrome experience an approximate doubling of cardiovascular disease risk (25), and metabolic syndrome is also associated with preclinical atherosclerosis measured by carotid intima-media thickness in men and women (35). Our findings identify reduced serum TOC as a risk predictor for metabolic syndrome in older men, raising the possibility that circulating osteocalcin might modulate cardiovascular risk.…”

Section: Discussionmentioning

confidence: 62%

Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels

Yeap¹,

Chubb²,

Flicker³

et al. 2010

European Journal of Endocrinology

149

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Objective: Bone-derived undercarboxylated osteocalcin regulates insulin secretion and sensitivity in mice, and reduced serum total osteocalcin (TOC) is associated with diabetes in humans. However, the relationship between TOC levels and other cardiovascular risk factors is uncertain. We sought to determine whether serum TOC is associated with metabolic syndrome and its components in older men. Design: Cross-sectional analysis from a population-based cohort of men aged R70 years. Methods: Early morning sera were assayed for TOC. Insulin resistance was estimated using a homeostatic model (HOMA2-IR). Metabolic syndrome was defined according to NCEP-ATPIII criteria. Results: TOC was assayed in 4047 men. Men who were not fasting and reported having bone fractures, Paget's disease, or bisphosphonate, glucocorticoid, or warfarin use were excluded, leaving 2765 men with metabolic syndrome present in 797 (28.8%). TOC was inversely associated with waist circumference, glucose, and triglyceride levels and HOMA2-IR (all P!0.001), and was lower in men with metabolic syndrome (meanGS.E.M.: 20.1G0.4 vs 21.4G0.2 mg/l, PZ0.002). In multivariate analysis, men with TOC of 13.25-16.55 and !13.25 mg/l had 1.5-to 2-fold increased risk of metabolic syndrome compared with men with levels R30 mg/l. TOC remained associated with metabolic syndrome after adjustment for individual components, but not after adjusting for both waist circumference and glucose. Conclusions: Increased waist circumference, reduced TOC, elevated glucose, and triglyceride levels are inter-related in aging men. Osteocalcin may lie in the causal pathway between central adiposity and insulin resistance. Further research is required to evaluate whether interventions which raise osteocalcin levels might decrease cardiovascular risk.

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Section: Discussionmentioning

confidence: 62%

Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels

Yeap¹,

Chubb²,

Flicker³

et al. 2010

European Journal of Endocrinology

149

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“…Similar to adults [5,104], two studies performed with children and adolescents found that cIMT was increased in obese patients with metabolic syndrome compared with those without [48,75]. Furthermore, the positive relation between the number of components of metabolic syndrome and cIMT [75] in children illustrated the early synergistic effects of cardiovascular risk factors clustering on the arterial wall that was also observed in adults [2,101,104]. A parallel may be drawn with the Bogalusa Heart Study [13], an autopsy study that found a positive relation between the number of vascular risk factors and the intimal surface of coronary arteries involving fatty streaks and fibrous plaques in people from 2 to 39 years of age.…”

Section: Discussionmentioning

confidence: 78%

Increased intima-media thickness of the carotid artery in childhood: a systematic review of observational studies

et al. 2010

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“…In particular, noninvasive imaging of carotid intima-media thickness (CIMT) and coronary artery calcium (CAC) scoring seem to have promising prognostic value in identifying patients at high risk [24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Serum heart type fatty acid binding protein levels in metabolic syndrome

Akbal

Özbek

Güneş

et al. 2009

Endocr

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Heart type fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is closely associated with acute coronary syndrome, hypertrophic and dilated cardiomyopathy, heart failure, stroke, obstructive sleep apnea syndrome, pulmonary embolism. The aim of this study was to investigate serum H-FABP value in the patients with metabolic syndrome (MetS). We measured serum H-FABP levels in 55 consecutive patients with MetS, and 73 age-matched control subjects by using a sandwich enzyme-linked immunosorbent assay. Serum H-FABP levels were significantly higher in patients with MetS than in control subjects 18.37 ± 13.0 and 7.9 ± 6.5 ng/ml, respectively, (P < 0.001). Serum H-FABP levels were significantly higher in patients with diabetic MetS than in without diabetic MetS, 24.0 ± 10.2 and 13.9 ± 12.6 ng/ml, respectively, (P: 0,003). There were statistically significant differences between patients without diabetic MetS and control subjects, 13.8 ± 12.6 and 7.9 ± 6.5 ng/ml, respectively, (P = 0.023). Patients with MetS have an increased risk of death from cardiovascular diseases. H-FABP seems to be a marker that will enable the detection of cardiac injury in the early asymptomatic period in patients with MetS.

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A Cross-sectional Study of Intima-Media Thickness, Ethnicity, Metabolic Syndrome, and Cardiovascular Risk in 2268 Study Participants

Abstract: The addition of IMT to the traditional criteria for the diagnosis of the MetS may help identify individuals who otherwise would not have been identified to be at high risk of CVD.

Cited by 34 publications

References 49 publications

Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels

Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels

Increased intima-media thickness of the carotid artery in childhood: a systematic review of observational studies

Serum heart type fatty acid binding protein levels in metabolic syndrome

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