A Critical Study of the Shay Rat

Madden, Robert J.; Ramsburg, Helen H.; Hundley, James M.

doi:10.1016/s0016-5085(51)80041-6

Cited by 42 publications

(4 citation statements)

References 2 publications

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“…This is intriguing, since it has been recognized long before that, that stomach distension could per se jeopardize the mucosal integrity (Madden et al, 1951). It could now be looked at this from the viewpoint of cytoprotection theory, and cytoprotective agent effect (Robert, 1979;Robert et al, 1983;Sikiric et al, 1997bSikiric et al, , d, 1999cMise et al, 2006).…”

Section: Therapeutic Potential Of Gastric Pentadecapeptide Bpc 157 Asmentioning

confidence: 99%

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Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response.

et al. 2006

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Gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419, safe in clinical trials for inflammatory bowel disease (PL 10, PLD 116, PLD 14736, Pliva, Croatia)) has a particular cytoprotective/adaptive cytoprotective activity. The cytoprotective/adaptive cytoprotection researches largely neglect that stomach distension could per se jeopardize the mucosal integrity, with constantly stretched mucosa and blood vessels, and sphincters more prone for reflux induction. After absolute alcohol instillation in fully distended rat stomach, gastric, esophageal and duodenal lesions occur. Throughout next 3 min, left gastric artery blood vessels clearly disappear at the serosal site, indicative for loss of vessels both integrity and function. Contrary, constant vessels presentation could predict the beneficial effect of applied agent. After pentadecapeptide BPC 157 instillation into the stomach the vessels presentation remains constant, and lesions of stomach, esophagus, and duodenum are inhibited. Standards (atropine, ranitidine, omeprazole) could only slightly improve the vessels presentation compared to control values, and they have only a partial effect on the lesions. In this review we emphasize BPC 157 unusual stability, and some of its important effects: effectiveness against various lesions in gastrointestinal tract, on nitric oxide (NO)-system, and NO-agents effects, on somatosensory neurons, salivary glands function, recovery of AMP-ADP-ATP system, endothelium protection, effect on endothelin, and on angiogenesis promotion. It also antagonizes other alcohol effects, including acute and chronic intoxication. Given peripherally, it counteracts the consequence of central dopamine system disturbances (receptor blockade), and induces serotonin release in substantia nigra. Therapeutic potential of BPC 157 as a cytoprotective agent is also seen in its capability to heal various wounds. Given directly into the stomach, BPC 157 instantly recovers disturbed lower esophageal and pyloric sphincter pressure in rats after 12-20 months of untreated esophagitis. All these could be suggestive for its role as a natural protectant in gastric juice with particular function throughout stomach distension.

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Section: Therapeutic Potential Of Gastric Pentadecapeptide Bpc 157 Asmentioning

confidence: 99%

“…The regular stomach mucosal integrity could be constantly jeopardized with the distension (Madden et al, 1951). Mucosa and blood vessels are stretched, and sphincters are more prone for refl ux induction.…”

Section: Introductionmentioning

confidence: 99%

Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response.

et al. 2006

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“…found that gastric ulceration with increased gastric secretion was produced in rats within 16 h of pyloric ligation, the ulcers being predominantly in the thin fundic portion. Vagotomy afforded complete protection against this response (Harkins, 1947;Shay, Komarov & Gruenstein, 1949;Madden, Ramsburg & Hundley, 1951;Donald & Code, 1952) whilst marked inhibition was found after treatment with anticholinergic drugs (Shay, Gruenstein & Jamison, 1951;Antonsen, 1953).…”

mentioning

confidence: 99%

Effect of aminoguanidine, chlorpromazine and NSD‐1055 on gastric secretion and ulceration in the Shay rat

Radwan

West

1971

British J Pharmacology

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“…4 h after pyloric ligation, animals were sacrificed by overdose of ether and the stomach was cut open along the greater curvature to do ulcer scoring. Gastric content was collected to determine gastric juice volume, gastric pH, free acidity, and total acidity [16].…”

Section: Antiulcer Activity Of Eepumentioning

confidence: 99%

Evaluation of Anti-Ulcer Activity of the Ethanolic Extract of Phyllanthus Urinaria in Experimental Animals

Deshpande¹,

Balekar

2018

Asian J Pharm Clin Res

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Objective: The objective of this study is to investigate the antiulcer activity of the ethanolic extract of Phyllanthus urinaria (EEPU). Methods: In vivo anti-ulcer activity of EEPU was evaluated in the present study at 500 mg/kg body weight by pyloric ligation, ethanol-induced ulcer, aspirin-induced ulcer, and cold restraint-induced ulcer model. The anti-ulcer activity was assessed by determining and comparing the gastric volume, pH, free and total acidity, ulcer number and its inhibition, and ulcer severity.Result: EEPU at 500 mg/kg body weight dose showed significant antiulcer activity by decreasing ulcer index, gastric volume, pH, and free and total acidity. Gastroprotective effect of EEPU was substantiated by histopathological studies of the stomach in ulcer and treated groups.Conclusion: It can be concluded from the results that EEPU has potential antiulcer activity.

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A Critical Study of the Shay Rat

Cited by 42 publications

References 2 publications

Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response.

Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response.

Effect of aminoguanidine, chlorpromazine and NSD‐1055 on gastric secretion and ulceration in the Shay rat

Evaluation of Anti-Ulcer Activity of the Ethanolic Extract of Phyllanthus Urinaria in Experimental Animals

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