A critical review on exploiting the pharmaceutical potential of plant endophytic fungi

Diversity and Antimicrobial Activity of Endophytic Fungi Isolated from Chloranthus japonicus Sieb in Qinling Mountains, China

“…Endophytic fungi have a high level of taxonomic diversity [ 19 ]. These fungi exist in nearly every tissue type studied and are promising as biological control agents against phytopathogens and bioactive substances [ 10 ]. Despite these characteristics, endophytic fungi remain poorly studied.…”

“…Endophytic fungi, which inhabit the interiors various plant tissues without causing disease or injury to the host, have a very complex relationship with their host plants [ 8 ]. The endophytic fungi not only produce hormones that promote plant growth and help the host resist abiotic stress but also produce bioactive secondary metabolites, including those originated from the host plants [ 9 , 10 ]. For instance, all the endophytic fungi taxa isolated from the Glycyrrhiza glabra have been reported to produce the plant growth promoting hormone indole acetic acid (IAA) [ 11 ].…”

Implications of endophytic microbiota in Camellia sinensis : a review on current understanding and future insights

“…Biotechnologically, endophytic microbiota function as an abundant source for production of various secondary metabolites, including alkaloids, terpenes, steroids, polyketides, quinones, iso-coumarins, esters, flavonoids, and lactones, et al [15,16]. Possessing antibacterial, antifungal, insecticidal, antioxidant, cytotoxic and anticancer properties [17], these microbiota-derived compounds enrich the chemical diversity of biologically active molecules and provide new ways for drug development [18]. More interestingly, some plant endophytic fungi were reported to produce secondary metabolites with high medicinal value, such as paclitaxel, camptothecin, et al [8,18], which provide solutions to the shortage of medical resources and ecological damage caused by the slow growth and shortage of certain medical plants, and can be used as a bioengineering tool for drug production [19].…”

Characterization of Nuclear and Mitochondrial Genomes of Two Tobacco Endophytic Fungi Leptosphaerulina chartarum and Curvularia trifolii and Their Contributions to Phylogenetic Implications in the Pleosporales

“…Previous studies have demonstrated that the interaction of plant endophytic fungi may be beneficial for plant growth and disease control [27]. In the process of agelong coevolution with host plants, endophytic fungi could produce various secondary metabolites with kinds of biological activities to assist tobacco in resisting biotic or abiotic stress, promote tobacco growth, and improve their bacteriostatic activities [28].…”