A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles

Abstract

Nitrogen containing heterocyclic compounds are biologically significant molecules. This is especially true for pyrrole a five membered nitrogen containing aromatic molecule, which is present as a key structural motif in a large number of drugs and lead molecules. This review aims to provide an overview of the multi-component reaction (MCR) based methodologies used for the synthesis of pyrrole and its derivatives, focusing particularly on eco-friendly methods that avoid the use of hazardous reagents, solvents and catalysts are deemed especially relevant to the disciplines of medicinal chemistry and drug discovery.

review on green multicomponent synthesis of heterocyclic compounds

“…Furthermore, we revealed saccharin as a strong corrosive impetus which has fostered another strategy in the field of green methodology which has significant advantages, for example, non-poisonous, eco-accommodating, green, high proficiently, naturally harmless nature, high reactant action, minimal expense [67]. 9) and chiral a-amino acid (10) under mild reaction conditions is developed for the synthesis of novel functionalized polycyclic N-fused pyrrolidine derivatives (11). This synthetic strategy results in the construction of two new CC bonds and one CN bond via a simple catalyst-free one-pot three-component reaction (Scheme-28High items yields are effortlessly acquired by basic filtration of the subsequent hastens and resulting washing with 3-5 mL MeOH (without section chromatography or recrystallization).…”

“…Heterocyclic compounds are the cyclic organic compounds which contain at least one hetero atom, the most common heteroatoms are the nitrogen, oxygen and sulphur but heterocyclic rings containing other hetero atoms are also widely known. Carbocyclic compound a cyclic organic compound containing all carbon atoms in ring formation [1][2][3][4][5][6][7][8][9][10][11][12][13].The most common heterocycles are those having five-or six-membered rings and containing heteroatoms of nitrogen (N), oxygen (O), or sulfur (S). The best known of the simple heterocyclic compounds are pyridine, pyrrole, furan, and thiophene.…”

“…Scheme 27: Synthesis of pyrazolo[1,2-b]phthalazine-5,10-dione derivatives They have reported a novel, highly efficient, eco-friendly, atom-economical one-pot three-component cascade reaction of acenaphthenequinone (8), b-nitroolefins (9) and chiral a-amino acid(10) under mild reaction conditions is developed for the synthesis of novel functionalized polycyclic N-fused pyrrolidine derivatives(11). This synthetic strategy results in the construction of two new CC bonds and one CN bond via a simple catalyst-free one-pot three-component reaction (Scheme-28High items yields are effortlessly acquired by basic filtration of the subsequent hastens and resulting washing with 3-5 mL MeOH (without section chromatography or recrystallization).…”

Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020

“…Pyrrole and its derivatives are nitrogen-containing heterocyclic compounds of great importance because they are highly distributed in of natural origin such as porphyrins, bacteriochlorins, porphyrinogens, chlorophyll, vitamin B12, bile pigments, such as bilirubin and biliverdin, and alkaloids isolated from marine sources [60]. In organic synthesis they are an outstanding building block to obtain bioactive compounds useful in medical chemistry and pharmacology.…”

Recent Advancements in Pyrrole Synthesis

“…Interestingly, between 2000 and 2020 over a dozen review articles have been published to summarize the various advancements that have been made to assemble this highly important molecular structure. [11][12][13][14][15][16][17][18][19][20][21][22][23][24] In this article, we wish to provide a brief survey on selected pyrrole syntheses that were published between 2014-2019. Upon examining literature precedents within this time span, we discerned that the various starting materials used in these new chemistries can be grouped broadly into four different types: substrates bearing -systems, substrates bearing carbonyl and other polar groups, and substrates bearing heterocyclic motifs ( Figure 2).…”