In this article, we describe in depth the analysis and solutions to manage the multiple coordinates of the sampling objects coming from the three different phases of the second Italian national forest inventory (Inventario Nazionale delle Foreste e dei serbatoi forestali di Carbonio [INFC]). In particular, this article describes the criteria used to determine the sample point coordinates of the first phase, the Global Positioning System (GPS) positioning procedure of the second phase, and the GPS-aided retrieval procedure of sample points during the third phase of the INFC. Because about two-thirds of the Italian territory is hilly or mountainous, with rough orography or with tree coverage, this article also provides a nationwide analysis and survey on the use of GPS technology in forest and natural environments.