A critical analysis of the use of sialic acid determination in the diagnosis of malignancy

O’Kennedy, Richard; Berns, Gerard; Morán, Eva; Smyth, Honor; Carroll, Kenneth; Thornes, R. D.; O’Brien, Amy; Fennelly, J. J.; Butler, Marcus W.

doi:10.1016/0304-3835(91)90029-h

Cited by 29 publications

(17 citation statements)

References 27 publications

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“…The degeneration of plasma membrane in the tumor cells and their leakage may account for the observed elevations of these glycoprotein components in cancer conditions. These causes may account for the elevation of hexoses, hexosamine, fucose and sialic acid, which reflect an increasing tumour burden [70]. In our study also glycoproteins, hexose, hexosamine and sialic acid levels were found to be significantly elevated in glioma bearing animals.…”

Section: Discussionmentioning

confidence: 72%

Studies on the neuroprotective role of Piper longum in C6 glioma induced rats

2009

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Many naturally occurring substances of plant origin ingested in human diet, exhibit anticarcinogenic and antimutagenic effects. One of the active phytochemical which shows the active anticarcinogenic role is Piper longum Linn. (Pl). Pl is widely used in ayurvedic industry due to its property in healing some of the bodily ailments. Despite being known for the antioxidant, antimicrobial and anticarcinogenic effects, its relation to brain and its tumour development is still scarce. Hence, the experimental glioma model was developed in rats using C6 glioma cells and the effect of Pl was evaluated in the brain tissue of experimental group of rats. From the study, the glioma induced animals showed an increased level of lipid peroxides (LPO), tissue marker enzymes lactate dehydrogenase (LDH), creatine kinase (CK), 5'nucleotidase (5'ND) and acetylcholine esterase (AChE). But Pl treatment (20 mg/kg body weight) significantly attenuated these alterations thereby showing potent anticancer effect in glioma induced rats. In addition, the anticarcinogenic effect of Pl was confirmed by microscopic analysis and the restoration of increased lipids and protein bound carbohydrates (PBCs) in the brain tissue of glioma induced rats. Hence our results implicate a major role for Pl in preventing the cancer development in the experimental glioma model.

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Section: Discussionmentioning

confidence: 72%

Studies on the neuroprotective role of Piper longum in C6 glioma induced rats

2009

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“…24) The mechanism of carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis on differentiation, inhibition of angiogenesis and antioxidation property of flavonoids may be responsible for growth inhibition. 25) Glycoproteins play a vital role in cell-to-cell recognition, 27) The elevated levels of hexose; hexosamine and sialic acid in cancerous conditions are useful indicators of carcinogenic process, and these changes alter the structure, rigidity and function of cell membranes. 28) In plasma, the increased levels of glycoprotein components in cancer condition may be due to the leakage of the disturbed membrane components from either disintegrating or dying neoplastic cells or as a consequent shedding of plasma membrane.…”

Section: Discussionmentioning

confidence: 99%

Anticancer Effect of Kalpaamruthaa on Mammary Carcinoma in Rats with Reference to Glycoprotein Components, Lysosomal and Marker Enzymes

Veena

Shanthi

Sachdanandam

2006

Biological & Pharmaceutical Bulletin

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Cancer accounts for high morbidity and high mortality rate throughout the world. Cancer of breast is common in women in developed countries and more than 40% of all breast cancer cases are found in developing countries.1) Cancer is based on genetic and epigenetic alterations that affect the regulation and function of genes. These pathologic changes are selected during progression to yield cells that multiply aggressively beyond the limits normally set by their intrinsic proliferative capacity, neighboring cells, limited mitogens, and blood supply. It is expected that the cataloging of specific changes in gene expression will provide diagnostic markers for any given type. Furthermore, proteins encoded by specific genes could potentially serve as targets for therapeutic intervention. 2)In addition to the therapeutic strategies already known, some recent reports indicate new areas for the development of target selective drugs for the treatment of metastatic breast cancer.3) The earliest adjuvant chemotherapy, with singleagent alkylating and anti-metabolic drugs, was soon replaced by combination therapy, as it was demonstrated that simultaneous combination of two or more agents provided better results. 4,5) Kalpaamruthaa is a Siddha formulation, which has been formulated in our laboratory. They contain Semecarpus anacardium LINN. (SA), Emblica officinalis and honey with different ratio. Kalpaamruthaa (KA) is a Siddha preparation which has been formulated in our laboratory, the components studies of this drug reveals the presence of flavonoids, ascorbic acid, polyphenols, tannins, sugars and sterols. Flavonoids are seemingly more widely dispersed in the food supply and are of more varied composition than are isoflavones. For these reason, their absorption and metabolism have been less completely characterized. Cameron and Pauling 6) believed that ascorbic acid combats cancer by promoting collagen synthesis and thus prevents tumors from invading other tissues. Flavonoids are polyphenols widely distributed and known to possess biological and pharmacological activities, including anti-inflammatory action against free radicals. 7)Isoflavonoids are members of the broad class of plant polyphenols that have been shown in vivo to have benefit in the treatment of a wide variety of chronic diseases, including cancer. Another important consideration in vivo is the localized metabolism of isoflavones that may occur in the vicinity of tumor cells. Many experiments to verify the association between isoflavone intake and disease prevention have been reported. 8)The biochemical evaluation of glycoprotein components, marker enzymes and lysosomal enzymes of liver, kidney and blood of control and experimental rats was carried out to study the therapeutic efficacy of KA on 7,12-dimethylbenz-(a)anthracene (DMBA) induced mammary carcinoma bearing rats (Sprague-Dawley strain). This study was undertaken to arrive at the effective dose of KA in mammary carcinoma condition in rats. MATERIALS AND METHODS MaterialsMammary carcinoma was induced ...

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“…The functions of sialic acids are to influence upon glycoprotein SILLANAUKEE ET AL conformation and to mask or serve as recognition sites (Schauer, 1982(Schauer, , 1985Rosenberg, 1995). Total SA and/or lipid-associated SA levels have been found among patients suffering from tumors, inflammatory disorders, diabetes, and cardiovascular diseases (Lindberg et al, 1991;O'Kennedy et al, 1991;Kokoglu et al, 1992;Tajiri et al, 1993;Xing et al, 1994;Ozben et al, 1995). It is known that alcohol consumption increases desialylation of transferrin and possibly of other glycoproteins.…”

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confidence: 95%