A critical analysis of cancer biobank practices in relation to biospecimen quality

Rush, Amanda; Spring, Kevin; Byrne, Jennifer A.

doi:10.1007/s12551-015-0178-2

Cited by 13 publications

(11 citation statements)

References 76 publications

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“…include guidance on issues such as material collection, processing, and use in addition to education and ethics can be used by bringing them into conformity with the legal framework of the biobank and the country's legislation (79) (82,83).…”

Section: Accreditationmentioning

confidence: 99%

Pathology and biobanking

Talu

Toper²,

Şahi̇n³

et al. 2020

TJPATH

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Biobanks are units where high quality and long-term protection of biomaterials is maintained. This system, in which biological materials and data are systematically recorded and stored, is a unique resource for the study of the pathophysiology of disease, the development of diagnostic biomarkers, and working with human tissues for the potential discovery of targeted therapeutic agents. At this point, the pathology unit plays a unifying and complementary role between the clinical and core disciplines and offers optimal management of the patients' biomaterials for diagnostic and research projects. The aim of this article is to present general information with regard to a biobank constructed for the storage of tumor tissue and blood biospecimens. Ethical issues (informed consent, protection of confidentiality and privacy, and secondary use of biospecimens) and the information technology system (collection, systematic recording, backup and protection of clinical information) are important issues in biobanking. The selection of freezers to be used in storage (mechanical freezers, liquid-vapor nitrogen tanks), and if mechanical freezers are preferred the establishment of the relevant infrastructure and support team (such as additional power units for protection from power outages), the preservation of materials by aliquoting in different freezers, ensuring financing so as to afford the cost of the infrastructure, and implementation of all these dynamics while adhering to international guidelines are of the utmost importance.

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Section: Accreditationmentioning

confidence: 99%

Pathology and biobanking

Talu

Toper²,

Şahi̇n³

et al. 2020

TJPATH

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show abstract

“…Different data from different sources [41] recommend consistency with biospecimens quality [42]. However, studies still report difficulties in obtaining sufficient high-quality bio-samples of diseased and control biological materials to come to definite conclusions [43,44].…”

Section: Role Of Harmonization Of Biobanking and Existing Initiatimentioning

confidence: 99%

Enriching Personalized Endometrial Cancer Research with the Harmonization of Biobanking Standards

Adishesh

Hapangama

2019

Cancers

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Endometrial cancer is the commonest gynecological cancer, with an incidence predicted to escalate by a further 50–100% before 2025, due to the rapid rise in risk factors such as obesity and increased life expectancy. Endometrial cancer associated mortality is also rising, depicting the need for translatable research to improve our understanding of the disease. Rapid translation of scientific discoveries will facilitate the development of new diagnostic, prognostic and therapeutic strategies. Biobanks play a vital role in providing biospecimens with accompanying clinical data for personalized translational research. Wide variation in collection, and pre-analytic variations in processing and storage of bio-specimens result in divergent and irreproducible data from multiple studies that are unsuitable for collation to formulate robust conclusions. Harmonization of biobanking standards is thus vital, in facilitating international multi-center collaborative studies with valuable outcomes to improve personalized treatments. This review will detail the pitfalls in the biobanking of biosamples from women with cancer in general, and describe the recent international harmonization project that developed standardized research tools to overcome these challenges and to enhance endometrial cancer research, which will facilitate future development of personalized novel diagnostic strategies and treatments.

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“…Another problem is that samples constantly vary in quality (Rush, Spring, & Byrne, 2015). This problem is accentuated by the fact that descriptions and terminology differ between countries as well as within countries, which in turn can make sample requests from different counties a logistical nightmare for researchers (Fransson, Rial-Sebbag, Brochhausen, & Litton, 2015).…”

Section: The Biobanking Situationmentioning

confidence: 99%

The 4 I’s of Entrepreneurship: A Study of the Entrepreneurial Perspectives behind A Failed Large-Scale Distributed Research Infrastructure

Larsson

2018

Entrepreneurship Research Journal

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This case study investigates whether collective entrepreneurial team cognition remains consistent throughout all stage processes when setting up a large-scale, distributed research infrastructure. A new “action phase model” has been devised, known as the “4 I’s of entrepreneurship”, with each “I” elucidating the entrepreneurial rationale behind various stages of the creation process: Intention, Initiation, Implementation and Introspection. The case investigated was BBMRI.se (BioBanking and Molecular Resource Infrastructure in Sweden) – a Swedish large-scale distributed research infrastructure aimed at harmonizing biobanking standards. Managers and key personnel involved in founding and/or operating the organization were interviewed. The results showed there was agreement regarding the need for the research infrastructure, while there were disagreeing perceptions of what the organization should be doing and regarding the difficulties it had faced. These developments would ultimately lead to BBMRI.se’s demise. The homogenous mindset would begin to dissipate once the Initiation stage was reached and worsened throughout the Implementation stage. The results indicate that BBMRI.se’s managerial structure, personal ambitions and lack of transparency and communication were key contributors to its ultimate failure. The implications highlight the risk of fragmented motivations as collective entrepreneurs turn their ambition into reality, if given too much autonomy.

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A critical analysis of cancer biobank practices in relation to biospecimen quality

Cited by 13 publications

References 76 publications

Pathology and biobanking

Pathology and biobanking

Enriching Personalized Endometrial Cancer Research with the Harmonization of Biobanking Standards

The 4 I’s of Entrepreneurship: A Study of the Entrepreneurial Perspectives behind A Failed Large-Scale Distributed Research Infrastructure

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