A critical analysis of a capsule dissolution test

Withey, R. J.; Mainville, C.A.

doi:10.1002/jps.2600580918

Cited by 29 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Luer fitting tuberculin syringe, graduated in 0.01-ml. units, was attached to a medium-porosity glass filter by means of a female Luer joint (16). This device eliminated most particulate matter from the transfer of the sample to volumetric flasks.…”

mentioning

confidence: 99%

Acetaminophen III: Dissolution Studies of Commercial Tablets of Acetaminophen and Comparison with In Vivo Absorption Parameters

Mattok¹,

McGilveray²,

Mainville³

1971

Journal of Pharmaceutical Sciences

Self Cite

View full text Add to dashboard Cite

mentioning

confidence: 99%

Acetaminophen III: Dissolution Studies of Commercial Tablets of Acetaminophen and Comparison with In Vivo Absorption Parameters

Mattok¹,

McGilveray²,

Mainville³

1971

Journal of Pharmaceutical Sciences

Self Cite

View full text Add to dashboard Cite

“…Capsules account for about 20% of all prescriptions dispensed. (Withey & Mainville, 1969) Two main types of capsules include:…”

Section: Introductionmentioning

confidence: 99%

Characterization and Evaluation of Capsules and Study of QC tests for Capsules

Pervaiz

Zahra

Qaiser

et al. 2018

GPSR

View full text Add to dashboard Cite

Using the capsule as a dosage form dates back to the early pharmacy days; from those days, the capsule preparation process is greatly evolved in order to meet the current needs of patients and the pharmaceutical industry. Currently, all pharmaceutical industries are making a dynamic change in the specifications of particular dosage forms such as capsules. It has become more difficult to obtain the higher valued drug product from the dosage form, along with the potential for improved delivery that can improve clinical outcomes. In addition, the capsules have played a significant role in drug development because of the hand filling or the production of semiautomatic capsular formulations, which have fewer requirements, and can be developed easily. The article will discuss different tests like Universal tests and specific tests, particularly for capsules, performed prior to the release of the batch to ensure efficacy and safety.

show abstract

“…This is because of bioavailability differences which have been observed in capsule formulation (Glasko et a1 1968;Brice & Hammer 1969). The variation in release of drugs from capsules has been shown to arise from the type of drug, other additives present and the method of preparation of the capsules (Withey & Mainville 1969;Samyn & Jung 1970;Newton et a1 1971a,b;Khalil & Ali 1972;Newton & Razzo 1974, 1977Newton & Bader 1980). An orally administered solid dosage form such as a capsule, will be subjected to a gradient of pH change ranging from acidic in the stomach (the average pH of gastric fluid in men is about 1-9, while it is reported to be approximately 2.6 for women, Dotevall 1961) to neutral medium in the intestine (the pH of the duodenal secretion for both men and women varies from 5.8 to 7.…”

mentioning

confidence: 99%

The influence of pH of dissolution fluid and particle size of drug on the in-vitro release of drug from hard gelatin capsules

Muhammad

Newton

1983

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

The influence of pH of the dissolution fluid on the in-vitro release of acetylsalicylic acid from hard gelatin capsules has been studied for a series of particle size fractions of the drug. Generally, the time required for 50% of the drug content of the capsule to appear in solution during a dissolution test, T50, increased as the pH increased from 1.2 to 2.0; thereafter the value of T50 decreased as the pH increased from 3 to 7. These changes were found to be related to the apparent solubility of the drug. The extent of the changes was found to be further dependent on the particle size of the drug. For capsules filled with particle size fractions of 2.5 and 5.5 microns median diameter, the changes were small. Larger changes were observed with particles of median diameters of 45, 100, 220 and 330 microns while the largest changes (greater than two-fold) were obtained with particles of median diameter 130 and 430 microns. The type of kinetics that could be used to express the release rates was found to be particle size-dependent. For particles of 45 microns and larger, the release rate followed an apparent zero order process while an apparent first order process represented the release for the two smallest particle size fractions.

show abstract

A critical analysis of a capsule dissolution test

Cited by 29 publications

References 15 publications

Acetaminophen III: Dissolution Studies of Commercial Tablets of Acetaminophen and Comparison with In Vivo Absorption Parameters

Acetaminophen III: Dissolution Studies of Commercial Tablets of Acetaminophen and Comparison with In Vivo Absorption Parameters

Characterization and Evaluation of Capsules and Study of QC tests for Capsules

The influence of pH of dissolution fluid and particle size of drug on the in-vitro release of drug from hard gelatin capsules

Contact Info

Product

Resources

About