A CRISPR way for accelerating improvement of food crops

Zhang, Yi; Pribil, Mathias; Palmgren, Michael G.; Gao, Caixia

doi:10.1038/s43016-020-0051-8

Cited by 140 publications

(96 citation statements)

References 48 publications

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“…In our view, the EU should embrace 'sustainable intensification' practices that use new technologies to boost crop yields. For example, gene-editing techniques (such as CRISPR-Cas) can enhance the edible mass, height and pest resistance of plants without using genes from another species 9 . Unlike the United States and China, the EU is currently treating CRISPR as conventional GM technology and lags behind them in CRISPR patents for agricultural use (18 in Europe, 61 in the United States and 259 in China) as well as in investments in such research 10 .…”

Section: Eu Import Driversmentioning

confidence: 99%

Europe’s Green Deal offshores environmental damage to other nations

Fuchs¹,

Brown²,

Rounsevell³

2020

Nature

124

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Section: Eu Import Driversmentioning

confidence: 99%

Europe’s Green Deal offshores environmental damage to other nations

Fuchs¹,

Brown²,

Rounsevell³

2020

Nature

124

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“…While genetically modifying quinoa using genome editing strategies seems to be feasible, such an approach would generate plants that might be subjected to strict GM regulation in some countries ( Zhang et al , 2020 ). For instance, a recent ruling of the European Court (Case C-528/16) has declared that any plant product generated with the use of new genome editing technologies is subjected to GM regulation, regardless of whether or not a transgene is present.…”

Section: Introductionmentioning

confidence: 99%

Prospects for the accelerated improvement of the resilient crop quinoa

López‐Marqués

Nørrevang

Ache

et al. 2020

Journal of Experimental Botany

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Abstract Crops tolerant to drought and salt stress may be developed by two approaches. First, major crops may be improved by introducing genes from tolerant plants. For example, many major crops have wild relatives that are more tolerant to drought and high salinity than the cultivated crops, and, once deciphered, the underlying resilience mechanisms could be genetically manipulated to produce crops with improved tolerance. Secondly, some minor (orphan) crops cultivated in marginal areas are already drought and salt tolerant. Improving the agronomic performance of these crops may be an effective way to increase crop and food diversity, and an alternative to engineering tolerance in major crops. Quinoa (Chenopodium quinoa Willd.), a nutritious minor crop that tolerates drought and salinity better than most other crops, is an ideal candidate for both of these approaches. Although quinoa has yet to reach its potential as a fully domesticated crop, breeding efforts to improve the plant have been limited. Molecular and genetic techniques combined with traditional breeding are likely to change this picture. Here we analyse protein-coding sequences in the quinoa genome that are orthologous to domestication genes in established crops. Mutating only a limited number of such genes by targeted mutagenesis appears to be a promising route for accelerating the improvement of quinoa and generating a nutritious high-yielding crop that can meet the future demand for food production in a changing climate.

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“…Extensive investigation in this field led to the development of new genome-editing tools, such as CRISPR/Cas9 and CRISPR/Cpf1 [12,13]. Initially, these techniques were developed in prokaryotes, because there were no efficient genome-editing techniques for eukaryotes at specific sites.…”

Section: Introductionmentioning

confidence: 99%

A Revolution toward Gene-Editing Technology and Its Application to Crop Improvement

Ahmar

Saeed

Khan

et al. 2020

IJMS

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Genome editing is a relevant, versatile, and preferred tool for crop improvement, as well as for functional genomics. In this review, we summarize the advances in gene-editing techniques, such as zinc-finger nucleases (ZFNs), transcription activator-like (TAL) effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR) associated with the Cas9 and Cpf1 proteins. These tools support great opportunities for the future development of plant science and rapid remodeling of crops. Furthermore, we discuss the brief history of each tool and provide their comparison and different applications. Among the various genome-editing tools, CRISPR has become the most popular; hence, it is discussed in the greatest detail. CRISPR has helped clarify the genomic structure and its role in plants: For example, the transcriptional control of Cas9 and Cpf1, genetic locus monitoring, the mechanism and control of promoter activity, and the alteration and detection of epigenetic behavior between single-nucleotide polymorphisms (SNPs) investigated based on genetic traits and related genome-wide studies. The present review describes how CRISPR/Cas9 systems can play a valuable role in the characterization of the genomic rearrangement and plant gene functions, as well as the improvement of the important traits of field crops with the greatest precision. In addition, the speed editing strategy of gene-family members was introduced to accelerate the applications of gene-editing systems to crop improvement. For this, the CRISPR technology has a valuable advantage that particularly holds the scientist’s mind, as it allows genome editing in multiple biological systems.

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A CRISPR way for accelerating improvement of food crops

Cited by 140 publications

References 48 publications

Europe’s Green Deal offshores environmental damage to other nations

Europe’s Green Deal offshores environmental damage to other nations

Prospects for the accelerated improvement of the resilient crop quinoa

A Revolution toward Gene-Editing Technology and Its Application to Crop Improvement

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