A covalent crosslinking strategy to construct a robust peptide-based artificial esterase

Abstract

Peptide-based artificial enzymes derived from the supramolecular assembly of short peptides have obtained growing attention in recent years. However, the stability of these artificial enzymes is still a problem since...

1-Naphthylacetic acid appended amino acids-based hydrogels: probing of the supramolecular catalysis of ester hydrolysis reaction

“… 36 Covalent cross-linked through di-tyrosine bond in peptide sequence YYHYY has also been investigated for efficient esterase-like activity. 37 The co-assembly of Fmoc–FFH–CONH 2 and Fmoc–FFR–CONH 2 into nanotubes is also efficient for nitrophenyl acetate hydrolysis. 38 14-Amino-acid-long peptides with general formula, NH 2 –X–SGQQKFQFQFEQQ–CONH 2 (where X = glycine/histidine/arginine) have been designed and synthesized for nanofiber preparation, followed by ester hydrolysis.…”