A coumarin-based biosensor for human hepatocellular carcinoma diagnosis with enhanced brightness and water solubility

Ma, Junyan; Xu, Yaoyu; Kong, Xiangtao; Wei, Yuying; Meng, Dan; Zhang, Zhenxing

doi:10.1039/d1qm00972a

Cited by 18 publications

(1 citation statement)

References 49 publications

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“…These fluorophores were chosen due to their good fluorescent response to biological stimuli and excellent stability in biological environments. [58][59][60] In particular, sensor 3 reacts with HNO to give highly fluorescent rhodol 10, which has high biostability to allow detection of subtle changes in concentrations of HNO in cells and tissues. In addition, this fluorophore emits at λ em = 550 nm, where biological samples typically have weaker autofluorescence relative to the turn-on brightness of the sensor, as demonstrated in this study.…”

Section: Resultschemistrymentioning

confidence: 99%

Multi-coloured fluorescent sensing toolbox for selective detection of nitroxyl in vitro and ex vivo

et al. 2022

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Section: Resultschemistrymentioning

confidence: 99%

Multi-coloured fluorescent sensing toolbox for selective detection of nitroxyl in vitro and ex vivo

et al. 2022

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Fluorescence Enhancement of Adamantane‐Modified Dyes in Aqueous Solution via Supramolecular Interaction with Methyl‐β‐cyclodextrin and Their Application in Cell Imaging

Liu,

Zhang,

et al. 2023

Chemistry A European J

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The fluorescence of functional dyes was generally quenched in aqueous solution, which hindered their application in water‐bearing detections. In this work, a novel strategy based on host‐guest interaction was provided for the purpose of fluorescence enhancement in aqueous solution and cell imaging. Three adamantane‐modified fluorescent dyes (Coum‐Ad, NP‐Ad, NR‐Ad) with coumarin, 1,8‐naphthalimide and Nile Red as fluorophores were initially designed and prepared. The ((adamantan‐1‐yl)methyl)amino group, as the auxochrome of those dyes, complexed with methylated β‐cyclodextrin (M‐β‐CD) via supramolecular interaction, and then fluorescent supramolecular nanoparticles (FSNPs) were formed by self‐assembly in water. The inclusion equilibrium constant (K) could be as high as 3.94×104 M−1. With the addition of M‐β‐CD, fluorescence quantum yields of these dyes were separately improved to 69.8 %, 32.9 % and 41.3 %. Inspired by the above satisfactory results, six adamantane‐modified probes organelle‐NPAds with organelle‐targeting capability were further obtained. As the formation of hydrogen bonds between organelle‐NPAd2 and M‐β‐CD verified by theoretical calculation, K of organelle‐NPAd2 (5.13×104 M−1~4.53×105 M−1) with M‐β‐CD was higher than that of organelle‐NPAd1 (1.15×104 M−1~3.66×104 M−1) and their fluorescence quantum yields increased to 32.8 %~83.6 % in aqueous solution. In addition, fluorescence enhancement was realized in cell imaging with the addition of M‐β‐CD.

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A dual-functional NIR fluorescence probe for detecting hypochlorous acid and bisulfite in biosystem

Ma,

Kong,

Zhao

et al. 2024

Analytica Chimica Acta

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A coumarin-based biosensor for human hepatocellular carcinoma diagnosis with enhanced brightness and water solubility

Abstract: Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide, which usually presents at a late stage and has a poor prognosis. Thus, there is an urge need for...

Cited by 18 publications

References 49 publications

Multi-coloured fluorescent sensing toolbox for selective detection of nitroxyl in vitro and ex vivo

Multi-coloured fluorescent sensing toolbox for selective detection of nitroxyl in vitro and ex vivo

Fluorescence Enhancement of Adamantane‐Modified Dyes in Aqueous Solution via Supramolecular Interaction with Methyl‐β‐cyclodextrin and Their Application in Cell Imaging

A dual-functional NIR fluorescence probe for detecting hypochlorous acid and bisulfite in biosystem

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