A cost-effective, fast cooling, and efficient anti-inflammatory multilayered topological hydrogel patch for burn wound first aid

Wang, Lina; He, Jing; Wu, Zhixin; Zhao, Qi; Lin, Tong; Ma, Hude; Zhang, Zhilin; Xu, Xinye; Zhong, Jun; Xu, Jingkun; Lu, Baoyang

doi:10.1016/j.cej.2022.140553

Cited by 14 publications

(5 citation statements)

References 47 publications

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“…The swelling ratio ( W s ) reveals the structural properties and cross‐linking density of the network and is calculated by Equation (1). 49,50

W_{normals} = (W_{normalt} - W_{0}) / W_{0}

where W t and W 0 are the weights of the swollen hydrogel at a specific time and the weights of dry hydrogel, respectively. The W s displays a maximum number at 400 min, followed by leveling off (Figure S11).…”

Section: Resultsmentioning

confidence: 99%

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Robust hydrogel sensors for unsupervised learning enabled sign‐to‐verbal translation

Qin

Xiao

et al. 2023

InfoMat

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Highly stretchable and robust strain sensors are rapidly emerging as promising candidates for a diverse of wearable electronics. The main challenge for the practical application of wearable electronics is the energy consumption and device aging. Energy consumption mainly depends on the conductivity of the sensor, and it is a key factor in determining device aging. Here, we design a liquid metal (LM)-embedded hydrogel as a sensing material to overcome the barrier of energy consumption and device aging of wearable electronics. The sensing material simultaneously exhibits high conductivity (up to 22 S m À1 ), low elastic modulus (23 kPa), and ultrahigh stretchability (1500%) with excellent robustness (consistent performance against 12 000 mechanical cycling). A motion monitoring system is composed of intrinsically soft LM-embedded hydrogel as sensing material, a microcontroller, signal-processing circuits, Bluetooth transceiver, and self-organizing map developed software for the visualization of multi-dimensional data. This system integrating multiple functions including signal conditioning, processing, and wireless transmission achieves monitor hand gesture as well as sign-to-verbal translation. This approach

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“…The swelling ratio ( W s ) reveals the structural properties and cross‐linking density of the network and is calculated by Equation (1). 49,50

W_{normals} = (W_{normalt} - W_{0}) / W_{0}

Section: Resultsmentioning

confidence: 99%

“…The gauge factor ( GF ) of the LM‐H hydrogel was defined as Equation (3). 50

GF = (Δ R / R_{0}) / ε

where Δ R , R 0 , and ε represent the resistance change of the hydrogel, the initial resistance, and the tensile strain of the hydrogel, respectively.…”

Section: Methodsmentioning

confidence: 99%

Robust hydrogel sensors for unsupervised learning enabled sign‐to‐verbal translation

Qin

Xiao

et al. 2023

InfoMat

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“…[118] If other materials, such as tannic acid or carboxymethyl cellulose are added to the hydrogels, it can be made into a wound dressing with anti-inflammatory, antibacterial, and isolating the surface of the wound from external contact. [119] For example, Zheng et al [120] designed a multilayered topological hydrogel patch for burn wound first-aid, which can rapidly cool, provide efficient anti-inflammatory effects, and protect wounds. The hydrogel products can also improve the skin permeability and help relax the skin barrier through skin hydration.…”

Section: Metal-drug Coordination Hydrogelsmentioning

confidence: 99%

“…[ 119 ] For example, Zheng et al. [ 120 ] designed a multilayered topological hydrogel patch for burn wound first‐aid, which can rapidly cool, provide efficient anti‐inflammatory effects, and protect wounds. The hydrogel products can also improve the skin permeability and help relax the skin barrier through skin hydration.…”

Section: Metal–drug Coordination Hydrogelsmentioning

confidence: 99%

Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

Wong,

Nie,

Wong

et al. 2024

Advanced Materials

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Drug delivery is a key component of nanomedicine, and conventional delivery relies on the adsorption or encapsulation of drug molecules to a nanomaterial. Many delivery vehicles contain metal ions such as metal‐organic frameworks, metal oxides, transition metal dichalcogenides, MXene and noble metal nanoparticles. These materials have a high metal content and pose potential long‐term toxicity concerns leading to difficulties for clinical approval. In this review, we summarize recent developments in the use of drug molecules as ligands for metal coordination forming various nanomaterials and soft materials. In these cases, the drug‐to‐metal ratio is much higher than conventional adsorption‐based strategies. The drug molecules are divided into small‐molecule drugs, nucleic acids, and proteins. The formed hybrid materials mainly include nanoparticles and hydrogels, upon which targeting ligands can be grafted to improve efficacy and further decrease toxicity. The application of these materials for addressing cancer, viral infection, bacterial infection inflammatory bowel disease, and bone diseases is reviewed. In the end, some future directions are discussed from fundamental research, materials science, and medicine.This article is protected by copyright. All rights reserved

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“…Various attempts have been made to develop and test dosage forms that can aid in skin regeneration, including nanoparticles [5], hydrogels [6], films [7], nanoemulsions [8], creams [9], sponges [10], gels [11], and nanofibers [12], Among these, hydrogels have proven superior [13] because they not only help sustain drug release but also because their inherent capability of absorbing large amounts of water enables them to maintain a moist environment at the wound bed in addition to wound debridement by adsorbing wound exudate, which is of paramount importance for speedy skin regeneration.…”

Section: Introductionmentioning

confidence: 99%

Chitosan based ethanolic Allium Sativum extract hydrogel film: a novel skin tissue regeneration platform for 2nd degree burn wound healing

Wang,

Ismail,

Khan

et al. 2024

Biomed. Mater.

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This study investigated the potential of ethanolic garlic extract-loaded chitosan hydrogel film for burn wound healing in an animal model. The ethanolic garlic extract was prepared by macerating fresh ground garlic cloves in ethanol for 24 h, followed by filtration and concentration using a rotary evaporator. Hydrogels were then prepared by casting a chitosan solution with garlic extract added at varying concentrations for optimization and, following drying, subjected to various characterization tests, including moisture adsorption (MA), water vapor transmission rate (WVTR), and water vapor permeability rate (WVPR), erosion, swelling, tensile strength, vibrational, and thermal analysis, and surface morphology. The optimized hydrogel (G2) was then analyzed in vivo for its potential for healing 2nd degree burn wounds in rats, and histological examination of skin samples on day 14 of the healing period. Results showed optimized hydrogel (G2; chitosan: 2 g, garlic extract: 1 g) had MA of 56.8% ± 2.7%, WVTR and WVPR of 0.00074 ± 0.0002, and 0.000 498 946 ± 0.0001, eroded up to 11.3% ± 0.05%, 80.7% ± 0.04% of swelling index, and tensile strength of 16.6 ± 0.9 MPa, which could be attributed to the formation of additional linkages between formulation ingredients and garlic extract constituents at OH/NH and C=O, translating into an increase in transition melting temperature and enthalpy (ΔT = 238.83 °C ± 1.2 °C, ΔH = 4.95 ± 0.8 J g−1) of the chitosan moieties compared with blank. Animal testing revealed G2 formulation significantly reduced the wound size within 14 d of the experiment (37.3 ± 6.8–187.5 ± 21.5 mm2) and had significantly higher reepithelization (86.3 ± 6.8–26.8 ± 21.5 and 38.2% ± 15.3%) compared to untreated and blank groups by hastening uniform and compact deposition of collagen fibers at the wound site, cementing developed formulation a promising platform for skin regeneration.

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A cost-effective, fast cooling, and efficient anti-inflammatory multilayered topological hydrogel patch for burn wound first aid

Cited by 14 publications

References 47 publications

Robust hydrogel sensors for unsupervised learning enabled sign‐to‐verbal translation

Robust hydrogel sensors for unsupervised learning enabled sign‐to‐verbal translation

Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

Chitosan based ethanolic Allium Sativum extract hydrogel film: a novel skin tissue regeneration platform for 2nd degree burn wound healing

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