A Corynebacterium striatum endocarditis on a carrier of pacemaker

Abi, Rachid; Ez-zahraouii, Khalil; Ghazouani, Mohammed; Zohoun, Alban; Kheyi, Jamal; Chaib, Ali; Elouennass, Mostafa

doi:10.1684/abc.2012.0707

Cited by 6 publications

(9 citation statements)

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“…The literature search results are summarized in Figure 1 . The final analysis covered a total of 42 studies (35 case reports 1 , 2 , 12 - 44 and 7 case series 5 , 9 , 45 - 49 ) reporting 85 individual cases that met the inclusion criteria and did not present exclusion criteria. The median age of the subject with the reported C. striatum invasive infection was 65 (IQR 51, 72), with the oldest being 88 years old, while the youngest was 13 years old.…”

Section: Resultsmentioning

confidence: 99%

“…Biofilm makes bacteria more resistant to the action of immune system cells and antibiotics, which explains the growing number of bloodstream and catheter-related infections caused by C. striatum 50 , 51 . Microbial biofilms play a key role in the pathogenesis of endocarditis 53 , which may explain the fact that this review includes as many as 10 reports of endocarditis caused by C. striatum 12 , 20 , 21 , 24 - 27 , 29 , 42 , 43 . We also analyzed more than 10 cases with C. striatum prosthetitis, catheter-related infections and similar infections on embedded artificial devices and materials 2 , 5 , 9 , 19 , 22 , 30 , which are most likely a consequence of the aforementioned virulence factor available to this bacterium.…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review

Milosavljević

Milosavljevic

Kočović

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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The aim of this study was to establish an evidence-based guideline for the antibiotic treatment of Corynebacterium striatum infections. Several electronic databases were systematically searched for clinical trials, observational studies or individual cases on patients of any age and gender with systemic inflammatory response syndrome, harboring C. striatum isolated from body fluids or tissues in which it is not normally present. C. striatum had to be identified as the only causative agent of the invasive infection, and its isolation from blood, body fluids or tissues had to be confirmed by one of the more advanced diagnostic methods (biochemical methods, mass spectrometry and/or gene sequencing). This systematic review included 42 studies that analyzed 85 individual cases with various invasive infections caused by C. striatum . More than one isolate of C. striatum exhibited 100% susceptibility to vancomycin, linezolid, teicoplanin, piperacillin-tazobactam, amoxicillin-clavulanate and cefuroxime. On the other hand, some strains of this bacterium showed a high degree of resistance to fluoroquinolones, to the majority majority of β-lactams, aminoglycosides, macrolides, lincosamides and cotrimoxazole. Despite the antibiotic treatment, fatal outcomes were reported in almost 20% of the patients included in this study. Gene sequencing methods should be the gold standard for the identification of C. striatum , while MALDI-TOF and the Vitek system can be used as alternative methods. Vancomycin should be used as the antibiotic of choice for the treatment of C. striatum infections, in monotherapy or in combination with piperacillin-tazobactam. Alternatively, linezolid, teicoplanin or daptomycin may be used in severe infections, while amoxicillin-clavulanate may be used to treat mild infections caused by C. striatum .

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review

Milosavljević

Milosavljevic

Kočović

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…Approximately 0.2 to 0.4% of native valve endocarditis is caused by Corynebacterium spp., while 9% of early and 4% of late prosthetic valve endocarditis are caused by members of the genus [ 9 , 10 ]. Although patients with implanted CRT-D may develop infectious endocarditis, obvious vegetation was never observed on echocardiography in these cases [ 11 ]. In addition, there is a report of a patient who underwent hemodialysis and developed sepsis caused by a Corynebacterium sp.…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium striatumBacteremia Associated with a Catheter-Related Blood Stream Infection

Ueno

Oishi

Yamane

et al. 2017

Case Reports in Infectious Diseases

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A 49-year-old woman visited our emergency department because of exertional dyspnea due to severe left ventricular functional failure. It progressed to disseminated intravascular coagulation and disturbance of consciousness on day 67 of admission. Gram-positive bacilli were detected from two different blood culture samples on day 67 of admission. An API-Coryne test and sequencing (1~615 bp) of the 16S rRNA gene were performed, and the strain was identified as Corynebacterium striatum. The bacterium was detected from the removed central venous catheter tip too, and the patient was diagnosed with catheter-related bloodstream infection by C. striatum. However, treatment was not effective, and the patient died on day 73 of admission.

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“…17 Most of the cases are managed with device removal and 2 weeks (uncomplicated) to 6 weeks (complicated) of targeted antibiotic therapy. 19 In light of this, C. striatum constitutes a rare cause of CIED infection with an unclear mortality; all patients reported thus far have survived via a combination of device removal and systemic antimicrobial therapy. 10,15,18 To our knowledge, 3 prior cases of CIED infection involving C. striatum are described in the literature: a case of tricuspid valve endocarditis in relation to a draining sinus tract contiguous to the generator device after recurrent erosions requiring 2 premorbid generator replacements; the second 2 months post pacemaker replacement with overt pocket infection leading to a lead vegetation.…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium striatum Cardiovascular Implantable Electronic Device Infection

Helbig¹,

Brecher²,

Serrao³

2013

Infectious Diseases in Clinical Practice

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We present a case of a 77-year-old male with persistent gram-positive nonYspore-forming bacillus bacteremia that developed several months after a right femoral-popliteal bypass for critical limb ischemia and a nonhealing toe amputation site. He required an implantable cardioverter defibrillator concomitantly for secondary prevention of ventricular fibrillation. Initially suspected to be a contaminant and subsequently growing from the implantable cardioverter defibrillator leads, all isolates were identified as Corynebacterium striatum. The patient was successfully treated with a prolonged course of antibiotics and explantation of the defibrillator. This represents the first case reported in the literature of Corynebacterium striatum cardiovascular implantable electronic device infection from an apparent noncontiguous source. Multiple isolates of indistinguishable diphtheroids from multiple blood cultures in patients with implantable devices should be considered clinically significant.

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A Corynebacterium striatum endocarditis on a carrier of pacemaker

Cited by 6 publications

References 0 publications

Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review

Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review

Corynebacterium striatumBacteremia Associated with a Catheter-Related Blood Stream Infection

Corynebacterium striatum Cardiovascular Implantable Electronic Device Infection

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