A correlativity study of plasma APL1β28 and clusterin levels with MMSE/MoCA/CASI in aMCI patients

Abstract

Amnestic mild cognitive impairment (aMCI) is a sub-clinical condition characterized by memory deficits that are not severe enough to affect daily functioning. Here we investigated two potential biomarkers found in the cerebrospinal fluid of AD patients, APLP1-derived Aβ-like peptides 28 (APL1β28) and clusterin plasma levels, in terms of their relationship to cognitive function, as reflected in the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA) and the Cognitive Assessment Screening Instrument (CASI) in aMCI patients. Forty-seven aMCI patients and thirty-five age- and gender-matched healthy adult controls were recruited for this study. Using the ELISA method, we found that the mean concentrations of both APL1β28 and clusterin were not significantly different between the control and aMCI groups. The APL1β28 levels were positively correlated with clusterin and that both were negatively correlated with the MMSE scores of the aMCI patients. Clusterin levels were negatively correlated with the MoCA and CASI scores of the aMCI patients. Using multivariate analysis, the correlation between clusterin and MMSE/MoCA/CASI was independent of other AD risk factors including age, education, sex, body mass index and ApoE genotype. The data presented here demonstrate that plasma clusterin levels reflect cognitive function in aMCI patients.

Plasma Clusterin and the CLU Gene rs11136000 Variant Are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients

“…Impairment in episodic memory function is the earliest change in presymptomatic stages of AD (Grober et al, 2008 ). Our results were consistent with the finding that plasma clusterin reflects cognitive function in MCI patients (Meng et al, 2015 ) and predicts increased entorhinal cortex amyloid burden, which is important in memory formation (Thambisetty et al, 2010 ). Several characteristic properties of clusterin make it related with the pathology of cognitive impairment.…”

“…Our results showed that plasma clusterin was correlated with MoCA scores in MCI patients, similar to findings of Meng et al ( 2015 ) and Schrijvers et al ( 2011 ), who studied MCI patients and AD patients, respectively. MoCA is a highly sensitive tool to distinguish MCI from cognitively healthy T2DM patients (Alagiakrishnan et al, 2013 ).…”

Integrated Cognitive Assessment: Speed and Accuracy of Visual Processing as a Reliable Proxy to Cognitive Performance

“…Given the variability in subject's demographics, such as age, gender, level of education, etc, a correlation above 0.4 with reference cognitive tests is considered within the acceptable range for construct validity 59 . As an example, cerebral spline fluid (CSF) and blood biomarkers' correlation with standard cognitive tests, such as MoCA, varies between 0.4 to 0.6 60,61 .…”

Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease

“…A recent study showed plasma ratio of Aß1-42/Aß1-40 was stepwise decreased from age-matched controls via MCI to AD and shows a clear correlation with memory scores 37 . Another study showed plasma clusterin level was negatively correlated with cognitive scores of patients with MCI 38 . These discrepancies may relate to the heterogeneous of MCI group, the different diagnostic criteria of MCI, fewer subjects sample size in our group and different measurement tools.…”