A Copper(II) Triflate‐Catalyzed Tandem Friedel–Crafts Alkylation/Cyclization Process towards Dihydroindenes

Abstract

A one-pot synthesis of dihydroindenes from substituted benzenes and haloalkenes was developed. The reaction proceeded via a copper(II) triflate [CuA C H T U N G T R E N N U N G (OTf) 2 ]-catalyzed tandem Friedel-Crafts alkylation/cyclization process with high efficiency under relatively mild conditions.

Copper(II)-Catalyzed Three-Component Arylation/Hydroamination Cascade from Allyl Alcohol: Access to 1-Aryl-2-sulfonylamino-propanes

“…Thus, the two isomeric allylic alcohols can act in this three-component coupling as butane-1,2-diylium or butane-1,3-diylium C4 synthons. Conversely, treatment of α,α- and γ,γ-dimethyl-substituted allyl alcohols afforded only diarylated derivatives with indane structures. , …”

Facile synthesis of dihydrochalcones via the AlCl3-promoted tandem Friedel–Crafts acylation and alkylation of arenes with 2-alkenoyl chlorides

“…A copper(II) triflate-catalyzed tandem Friedel-Crafts alkylation/cyclization process was developed to prepare dihydroindenes [10]. Indenoindene-fused ␣-methylene-␥-butyrolactones were synthesized via a tandem intra-and intermolecular Friedel-Crafts reaction [11].…”