A convenient synthesis of novel symmetrical bis-Schiff bases of 2, 2'-thio-bis[4-methyl(2-aminophenoxy)phenyl ether] in solution and under solvent-free conditions

Abstract

A convenient and straightforward procedure for the synthesis of novel symmetrical bis-Schiff bases has been achieved through the condensation of the symmetrical primary bis-amine 2,2'-thio-bis[4-methyl(2-aminophenoxy) phenyl ether] with a series of aryl aldehydes in organic solvents at room temperature and in solvent-free media, in moderate to high yields.

Synthesis of New Series Bis-3-Chloro-β-Lactam Derivatives from Symmetrical Bis-Schiff Bases as Effective Antimicrobial Agents with Molecular Docking Studies

“…Synthesis and characterization of Schiff bases and their corresponding heterocyclic derivatives are very important because of their biological importance. Recently abundant Schiff bases synthesized as probable bioactive core (Kajal et al, 2013, Shockravi et al, 2009, which present a significant role as an intermediate in the synthesis of some bioactive compounds such as β-lactams (Anacona and Acosta, 2006). The small molecule azomethines are explored as the conjugated linker unit for photovoltaic application (Petrus et al, 2014).…”