Synthesis of New Series Bis-3-Chloro-β-Lactam Derivatives from Symmetrical Bis-Schiff Bases as Effective Antimicrobial Agents with Molecular Docking Studies

Abstract

Endeavoring to find a new type of antimicrobial agents, a new sequence of bis-Schiff bases and bis-3-cholro-β-lactams are synthesized. An astonishing class of strained compounds is part of the symmetrical bis-Schiff bases that has widespread applications and building blocks for the combination of bis-3-cholro-β-lactams antibiotics. Bis-3-cholro-β-lactams are synthesized through (Staudinger) [2+2] ketene-imine cycloaddition reaction. Structures of the produced compounds are deduced by 1H, 13C-NMR, and FT-IR spectroscopies. All produced compounds are shown moderate to good antimicrobial activity compared to human pathogenic bacteria strains (Escherichia coli and Staphylococcus aureus), also compared to Aspergillus Niger and Trichophyton mentagrophytes fungi through the broth microdilution technique. A molecular docking study is used for showing the active sides and binding affinity of the products with the target proteins or receptors of E. coli (PDB ID: 3GI9).

Synthesis, Characterization, and Evaluation of Tetrazole Derivatives with Pyrrole‐2,5‐Dione Moieties as Urease Inhibitors: Exploring Structure‐Activity Relationships and Computational Insights

“…[16][17][18][19] Consequently, heterocyclic compounds have emerged as key components in the synthesis of therapeutics for a wide range of diseases, including cancer, [20] infectious diseases, and neurological disorders. [21][22][23][24][25] Numerous efforts have been made to enhance the urease inhibitory potency and selectivity of existing azole drugs by modifying their structures. [26][27][28] Despite the potential antibacterial and antifungal activities associated with certain tetrazoles, the role of the tetrazole moiety in this pharmacophore has been largely overlooked, with only a few studies addressing it.…”

“…The incorporation of nitrogen atoms within the heterocyclic ring imparts unique electronic and steric properties, influencing their interactions with biological macromolecules [16–19] . Consequently, heterocyclic compounds have emerged as key components in the synthesis of therapeutics for a wide range of diseases, including cancer, [20] infectious diseases, and neurological disorders [21–25] . Numerous efforts have been made to enhance the urease inhibitory potency and selectivity of existing azole drugs by modifying their structures [26–28] .…”

A synergistic investigation of azo-thiazole derivatives incorporating thiazole moieties: a comprehensive exploration of their synthesis, characterization, computational insights, solvatochromism, and multimodal biological activity assessment

“…Advances in pharmaceutical chemistry and drug delivery give rise to extended-release formulations, boosting patient compliance and treatment efficacy. [6][7][8][9] Recently, bacterial and inammatory infections have given rise to diverse and serious diseases. Thus, the discovery of novel antibacterial and anti-inammatory agents holds promise for mitigating these medical challenges.…”