A convenient preparation of 2-substituted (S)-aziridines

Efficient Synthesis of Taurine and Structurally Diverse Substituted Taurines from Aziridines.

“…1 Their analytic data are identical to the reported ones. [1][2][3][4][5][6][7][8] Other reactants are commercial available and were used without further purification. All solvents were used without purification.…”

High‐Throughput Preparation of Optically Active Cyanohydrins Mediated by Lipases

“…Cyanohydrin esters (1)(2)(3)(4)(5)(6)(7)(8) were synthesized in two consecutive reactions. Firstly, cyanohydrins were prepared from the corresponding aldehydes.…”

“…Cyanohydrins are versatile compounds with several applications as chiral building blocks. [1] In this context, they can be used as precursors of -amino alcohols, [2] α-hydroxy acids, [3] α-hydroxy ketones, [4] and other compounds with high added value in the pharmaceutical industry. [5] Cyanohydrins have already been used as precursors of different drugs, such as fluoxetine, duloxetine and its derivatives, [6] capuramycin, [7] bufuralol, [8] denopamine, and salbutamol.…”

Nitrilase‐Catalyzed Selective Hydrolysis of Dinitriles and Green Access to the Cyanocarboxylic Acids of Pharmaceutical Importance

“…Nitrilase-catalyzed hydrolysis of nitriles offers a "greener" alternative, [1] because this eco-friendly biotransformation allows the clean and mild synthesis of carboxylic acids with high yield and selectivity. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] Cyanocarboxylic acids are important intermediates for a variety of applications. For example, 1-cyanocyclohexaneacetic acid is a useful precursor for the synthesis of gabapentin.…”

“…The general procedure was followed: 1-Cyanocyclopentaneacetonitiles (200 mg, 1.31 mmol) was treated with the nitrilase (10 mg, 13.5 U) in potassium phosphate buffer (50 mL, 100 mM, pH 7.2). The reaction mixture was incubated at 30 8C and the reaction was monitored by 13…”