Efficient Synthesis of Taurine and Structurally Diverse Substituted Taurines from Aziridines.

Abstract

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Controlling the Size of Taurine Crystals in the Cooling Crystallization Process

“…Increasing the crystal size will lead to better flowability and reduction in caking in terms of bulk properties due to the decrease of the surface area per unit mass, which subsequently reduces the interparticle cohesive strength . Crystal shapes also influence those properties due to the changes of the surface contact between the crystals. , To date, many papers have been published on the topic of controlling crystals’ size and shape for other amino acid crystals via cooling crystallization. − The manipulations were conducted by adjusting seeding ratio, temperature profile, cooling rate, solution concentration, and other parameters in the batch crystallization. − In particular, a controlled process with in situ solution concentration measurement and crystal number determination was reported to be able to adjust final mean sizes of glycine and l -glutamate crystals. ,, However, taurine-related studies have mainly focused on the separation methods to extract taurine from biological samples, the chemical synthesis, and the physiological function. − Few studies specifically manipulating the size and shape of TCs produced by cooling crystallization processing under various conditions are available. , …”