A convenient and efficient one-pot method for the synthesis of novel acridine-calix[4]arene derivatives as new DNA binding agents via multicomponent reaction

Abstract

2014) A convenient and efficient one-pot method for the synthesis of novel acridine-calix[4]arene derivatives as new DNA binding agents via multicomponent reaction, Supramolecular Chemistry, 26:5-6, 442-449, A new approach is applied for the synthesis of novel acridine-calix[4]arene derivatives via a multicomponent reaction. These compounds have been characterised by 1 H NMR, 13 C NMR and HR-MS. Our binding studies between acridinefunctionalised calix[4]arenes and calf thymus DNA (CT-DNA) via fluorescence titration show that these compounds have a good affinity to CT-DNA.

Functionalized calix[4]arene-based receptor for saccharide recognition

“…All commercially available materials were used as received. The acridine-calix [4]arene derivatives 1, 2 and 3 were synthesized according to our previously reported methods [39].…”

“…Recently we have synthesized acridine-calix [4]arene derivatives 1, 2, 3 via multicomponent reaction (MCR) of aminocalix [4]arene with dimedone and 3-hydroxybenzaldehyde or 4-bromobenzaldehyde which selectively bind Calf Thymus DNA and ds DNA with submicromolar K f values in buffered aqueous solution (Scheme 1) [39].…”

An Efficient Multi‐Component Synthesis of Highly Functionalized Calix[4]arenes with Pronounced Binding Affinity toward β‐Lactoglobulin

“…A survey of the literature shows that there are only a few reports for the preparation of calix[4]arene derivatives through MCR protocols . Recently, Varma and co‐workers reported the synthesis of calix[4]arene peptoids by means of the well‐known Ugi four‐component reaction …”

“…Based on the above information and as a part of our continuing interest in supramolecular chemistry,, , we report herein the synthesis of new calix[4]arene‐hexaamide derivatives by multi‐component reactions in good yields (70–86 %) under mild conditions. The binding affinity of these new calix[4]arenes toward β‐lactoglobulin (BLG) as a model protein was investigated by using fluorescence spectrophotometric methods.…”

Efficient synthesis of lower rim α-hydrazino tetrazolocalix[4]arenes via an Ugi-azide multicomponent reaction

“…5b As part of our interest in the synthesis of functionalized calixarenes, we reported the synthesis of a number of functionalized calixarenes using multi-component reactions. 8 Multicomponent reactions (MCRs) are compelling strategies for the rapid generation of diverse sets of complex molecules. 9 Among MCRs, isocyanide-based multicomponent reactions (IMCRs) by virtue of their synthetic potential, inherent atom efficiency, convergent nature, ease of implementation, and generation of molecular diversity have attracted considerable attention of organic chemists, medicinal chemists and pharmacologists worldwide.…”