An Efficient Multi‐Component Synthesis of Highly Functionalized Calix[4]arenes with Pronounced Binding Affinity toward β‐Lactoglobulin

Abstract

A facile and convenient approach for the synthesis of multi‐functionalized calix[4]arenes through multi‐component reactions is described. A series of five new calix[4]arene‐hexaamide derivatives were synthesized, and their structures were elucidated by means of spectroscopic data. The value of this method lies in its operational simplicity, mild reaction conditions, structural diversity of products, and good yields. Furthermore, fluorescence studies demonstrated considerable binding affinity of these new calix[4]arenes toward β‐lactoglobulin protein.

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“…The obtained results disclosed that any change in microenvironment of the tryptophan and tyrosine did not occur. 53 Also, the binding affinity of compound 3f toward some proteins has been investigated in a similar study (Scheme 7). Surprisingly, it was found that the binding affinity of 3f toward lysozyme (Lys) is signicantly higher than the others (Table 2).…”

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“…Thus, the synthetic of highly functionalized calix[4]arene derivatives has become an active area of research. Recently, we have reported that highly functionalized calix[4]arenes have significant binding at proteins .…”