A Controversial New Approach to Address Hematological Parameters in Hashimoto's Thyroiditis

Arpacı, Dilek; Gürol, Gönül; Ergenç, Hasan; Yazar, Hayrullah; Toçoğlu, Aysel; Çiftçi, İhsan Hakkı; Tamer, Ali

doi:10.7754/clin.lab.2015.150927

Cited by 8 publications

(12 citation statements)

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“…However above mentioned study from Arpaci D et al studied MPV parameter in Hashimoto Thyroiditis but had found no significance. 25 Limitations of the study: This is a single-center study is a relatively small number of cases and a limited follow-up period. For example, sometimes the development of permanent hypothyroidism may extend to 12 months, but unfortunately, we were unable to get 12 months of data for most of our patients.…”

Section: Discussionmentioning

confidence: 99%

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Hemogram parameters in the patients with subacute thyroiditis

et al. 2019

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Background & Objective: Subacute Granulomatous Thyroiditis (De Quervain’s Thyroiditis) is an acute painful inflammatory disease of the thyroid. We aimed to investigate easily accessible and cheap hemogram based parameters of Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) in the follow up of inflammatory thyroid disease. Methods: Patients admitted to Sakarya University Education and Research Hospital Endocrinology and Metabolism Outpatient Clinic and diagnosed as Subacute Granulomatous Thyroiditis between May 2017 and November 2018 were included in the study. Hemogram, thyroid function tests and acute phase values of these patients were recorded and compared with the values after treatment and disease recovery. On the sixth month, thyroid function tests were repeated and the rate of permanent hypothyroidism was screened. The relationships between initial hemogram parameters and acute phase reactants were evaluated. Results: Total 71 patients were included in our study. 60 (84.5%) were female and 11 (15.5%) were male. The F/M ratio was found to be 6/1. Mean age was 43 ± 9.95 years. Receiver Operating Characteristics (ROC) Curve Analysis was performed and values for Area Under the Curve (AUC) for NLR and PLR, respectively, were 0.739 (95% CI 0.657-0.820 p<0.0001) and 0.772 (95% CI 0.694-0.850 p<0.0001), which are significant and associated with disease activity. However, the AUC for MPV parameter was: 0.578 (95% CI 0.484-0.672 P: 0.10) and was not significant. The cut off values defined as 2.4 (80% sensitivity and 51% specificity) for NLR and 146.84 (83% sensitivity and 54% specificity) for PLR for the acute phase of the disease. In the Correlation Analysis, NLR and PLR values were significantly correlated with ESR and CRP parameters, which are the most commonly used acute phase reactants. Conclusion: According to the present study, we believe that the NLR and PLR parameters will be of benefit in the follow-up the disease, accurately demonstrate the inflammatory load in the acute phase of the disease, and correlate with the common acute phase reactants. doi: https://doi.org/10.12669/pjms.36.2.1063 How to cite this:Cengiz H, Varim C, Demirci T, Cetin S. Hemogram parameters in the patients with subacute thyroiditis. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.1063 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

“…The MPV parameter was also examined but no significant differences were found as in our study. 25 Neutrophil to Lymphocyte Ratio and PLR in Thyroid Cancer have been investigated in many studies as well. [26][27][28][29] Significant correlations between NLR and PLR and prognostic factors were recorded in most of these studies.…”

Section: Discussionmentioning

confidence: 99%

Hemogram parameters in the patients with subacute thyroiditis

et al. 2019

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“…Several authors proved that NLR may be a useful parameter in the differential diagnosis of benign thyroid nodules from malignant tumors, especially papillary thyroid carcinoma [ 17 , 37 , 38 ]. Aside from thyroid neoplasms, NLR combined with PLR have been studied as potential indicators of Hashimoto’s disease occurrence, which can allow to distinguish patients with chronic autoimmune thyroiditis from healthy individuals [ 22 , 23 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, NLR and PLR could serve as indicators to differentiate malignant from benign thyroid nodules in preoperative period as well as they may be predictors of response to treatment, progression of the disease, risk of recurrence, and mortality rate in thyroid cancers [ 17 , 18 , 19 , 20 ]. Literature data about the role of NLR, MLR and PLR in chronic autoimmune thyroid diseases are still lacking [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. There are only single studies evaluating the relationship between these direct and indirect blood-cell associated inflammatory markers and GO [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Relation to Clinical Parameters and Smoking Status in Patients with Graves’ Orbitopathy—Novel Insight into Old Tests

Szydełko

Litwińczuk

Szydełko

et al. 2020

JCM

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Graves’ orbitopathy (GO) is an autoimmune disease with a chronic inflammatory background. Smoking behavior is the main environmental factor responsible for the transition of this major extra thyroidal manifestation of Graves’ disease (GD) from the subclinical to the overt form. Complete blood count-derived parameters are suggested to be novel inflammatory indices. The aim of this retrospective study was to investigate the association between neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte ratios (PLR) with selected clinical parameters and smoking status in 406 GD patients with (n = 168) and without GO (n = 238). The control group consisted of 100 healthy individuals. The activity of GO was graded according to Clinical Activity Score. Significantly higher white blood cells (WBC), neutrophil, and NLR (p < 0.05) values were observed in GD patients with GO compared with those without GO. PLR values were significantly higher in GO patients than in the controls. WBC (6.81 ± 1.56 vs. 5.70 ± 1.23) and neutrophils (3.89 ± 1.06 vs. 3.15 ± 0.95) count was higher in active GO patients than in those with inactive GO. Positive correlation (p < 0.05) between CAS score and WBC, neutrophil and monocyte count, and NLR was found. Smoking was associated with higher WBC (p = 0.040), neutrophil (p = 0.049), PLR (p = 0.032) values. Multivariate analysis revealed that WBC, NLR may be risk factors for GO development. WBC, neutrophil, NLR and PLR values seem to be useful tools in the assessment of inflammation in GD.

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“…The association of elevated NLR with advanced disease and prognosis has been elucidated quite well in various malignancies (15,16). In addition, NLR has been elevated in autoimmune diseases like systemic lupus erythematosus (SLE) (9,25,26), rheumatoid arthritis (RA) (10), Sjögren's syndrome (27), and autoimmune thyroiditis (28,29). Also, increased NLR was shown to be an indicator of disease activity in SLE (26), RA (10,30), and Sjögren syndrome (27).…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio in Estimating Response to Corticosteroid Treatment in Immune Thrombocytopenia Patients

Eren¹,

Ünaldı²,

Karışmaz³

et al. 2019

Istanbul Med J

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Inflammation is known to have a significant role in the course of many benign (6) and malignant diseases (7). Neutrophil lymphocyte ratio (NLR), being an inexpensive and easily available parameter, has been used frequently as a marker of systemic inflammation in recent years (6). The association between elevated NLR and the disease course, prognosis and treatment response has been established in several benign (8-14) and malignant (15,16) diseases.

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A Controversial New Approach to Address Hematological Parameters in Hashimoto's Thyroiditis

Abstract: A single marker or panel of biomarkers is not a consistent indicator of HT, but NLR combined with PLR testing may offer a more reliable diagnosis.

Cited by 8 publications

References 0 publications

Hemogram parameters in the patients with subacute thyroiditis

Hemogram parameters in the patients with subacute thyroiditis

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Relation to Clinical Parameters and Smoking Status in Patients with Graves’ Orbitopathy—Novel Insight into Old Tests

Neutrophil Lymphocyte Ratio in Estimating Response to Corticosteroid Treatment in Immune Thrombocytopenia Patients

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