A controlled surface geometry of polyaniline doped titania nanotubes biointerface for accelerating MC3T3-E1 cells growth in bone tissue engineering

Bhattarai, Deval Prasad; Shrestha, Sita; Shrestha, Bishnu Kumar; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.cej.2018.05.162

Cited by 45 publications

(42 citation statements)

References 63 publications

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“…Bone tissue engineering aims at growing ECM via seeding bone cells on synthetic scaffolds. Bone tissue scaffolds can be made by various techniques, such as electrospinning [ 69 ], hydrogel gel formation method [ 70 , 71 ], electrochemical anodization of metal [ 17 ], and thermally-induced phase separation method [ 72 ]. The commonly used biomaterials in bone tissue scaffolds are β-TCP ceramics [ 73 ], hydroxyapatite [ 74 , 75 ], bioactive glass [ 76 ], metal or alloy [ 77 ], and nano/micro fiber-based scaffolds.…”

Section: Native Bone Structure and Compositionmentioning

confidence: 99%

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A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

2018

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Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.

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Section: Native Bone Structure and Compositionmentioning

confidence: 99%

“…Bone tissue scaffolds may be metallic [ 8 ], hydrogels [ 9 , 10 , 11 ], or electrospun nano/microfibers [ 12 , 13 , 14 ]. Commonly used metallic bio-implants includes stainless steel [ 15 , 16 ], titanium [ 17 ] or its alloys, nitinol, etc. [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

2018

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“…We used a three-electrode electrochemical configuration, where Mg or modified Mg samples were used as working electrodes, saturated calomel electrode (SCE) was used as reference electrode, and platinum mesh was used as counter electrode. Inorganic salts of magnesium sulfate, calcium chloride, and sodium bicarbonate, along with Hank's balanced salts (H2387, Sigma Aldrich, Korea), were dissolved in 1 L of DI water (pH 7.4) in accordance with the literature [27], and the solution-simulated body fluid (SBF) was used as electrolyte for each electrochemical measurement at RT. The potentiostatic electrochemical impedance spectroscopy (EIS) was recorded from all surface-modified and pure Mg in SBF solution (pH 7.4) at an amplitude of 10 mV and zero bias potential in the frequency range (100 kHz-1 mHz).…”

Section: Electrochemical Measurementmentioning

confidence: 99%

Covalent Surface Functionalization of Bovine Serum Albumin to Magnesium Surface to Provide Robust Corrosion Inhibition and Enhance In Vitro Osteo-Inductivity

Lee

Shrestha

et al. 2020

Polymers

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Herein, we describe precisely a covalent modification of pure magnesium (Mg) surface and its application to induce in vitro osteogenic differentiation. The new concept of a chemical bonding method is proposed for developing stable chemical bonds on the Mg surface through the serial assembly of bioactive additives that include ascorbic acid (AA) and bovine serum albumin (BSA). We studied both the physicochemical and electrochemical properties using scanning electron microscopy and other techniques to confirm how the covalent bonding of BSA on Mg can, after coating, significantly enhance the chemical stability of the substrate. The modified Mg-OH-AA-BSA exhibits better anti-corrosion behavior with high corrosion potential (Ecorr = −0.96 V) and low corrosion current density (Icorr = 0.2 µA cm−2) as compared to the pure Mg (Ecorr = −1.46 V, Icorr = 10.42 µA cm−2). The outer layer of BSA on Mg protects the fast degradation rate of Mg, which is the consequence of the strong chemicals bonds between amine groups on BSA with carboxylic groups on AA as the possible mechanism of peptide bonds. Collectively, the results suggest that the surface-modified Mg provides a strong bio-interface, and enhances the proliferation and differentiation of pre-osteoblast (MC3T3-E1) cells through a protein–lipid interaction. We therefore conclude that the technique we describe provides a cost-effective and scalable way to generate chemically stable Mg surface that inherits a biological advantage in orthopedic and dental implants in clinical applications.

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“…Indeed, the crosslinked PHEMA-EGDMA coating displayed a smooth and continuous surface, which promoted fibroblasts elongation, while the uncrosslinked PHEMA coating, with its more porous structure, improved cell adhesion and spreading. More recently, Bhattarai et al electrosynthesized a poly(aniline) coating via cyclic voltammetry, using a titanium-anodized substrate with nanotubular geometry [77]. Their work demonstrated the role of the polymeric coating in enhancing pre-osteoblasts attachment, spreading and osteogenic differentiation.…”

Section: Bioactive Coatings: From Drug-eluting Systems To Antimicrobimentioning

confidence: 99%

Electrochemical Strategies for Titanium Implant Polymeric Coatings: The Why and How

et al. 2019

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Among the several strategies aimed at polymeric coatings deposition on titanium (Ti) and its alloys, metals commonly used in orthopaedic and orthodontic prosthesis, electrochemical approaches have gained growing interest, thanks to their high versatility. In this review, we will present two main electrochemical procedures to obtain stable, low cost and reliable polymeric coatings: electrochemical polymerization and electrophoretic deposition. Distinction should be made between bioinert films—having mainly the purpose of hindering corrosive processes of the underlying metal—and bioactive films—capable of improving biological compatibility, avoiding inflammation or implant-associated infection processes, and so forth. However, very often, these two objectives have been pursued and achieved contemporaneously. Indeed, the ideal coating is a system in which anti-corrosion, anti-infection and osseointegration can be obtained simultaneously. The ultimate goal of all these coatings is the better control of properties and processes occurring at the titanium interface, with a special emphasis on the cell-coating interactions. Finally, advantages and drawbacks of these electrochemical strategies have been highlighted in the concluding remarks.

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A controlled surface geometry of polyaniline doped titania nanotubes biointerface for accelerating MC3T3-E1 cells growth in bone tissue engineering

Cited by 45 publications

References 63 publications

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

Covalent Surface Functionalization of Bovine Serum Albumin to Magnesium Surface to Provide Robust Corrosion Inhibition and Enhance In Vitro Osteo-Inductivity

Electrochemical Strategies for Titanium Implant Polymeric Coatings: The Why and How

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