A controlled study showing significant short term effect of prostaglandin el in healing of ischaemic ulcers of the lower limb in man

ACC/AHA 2005 Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Surgery,⁎Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients

“…There have been at least 8 short-term trials of parenteral administration of PGE-1 or prostacyclin in patients with CLI. The results have been inconsistent and for the most part have not demonstrated efficacy in terms of amelioration of pain or healing of ulcers (1,(521)(522)(523)(524)(525)(526)(527). In addition, there have been at least 11 randomized, placebo-controlled trials of intravenous PGE-1, or iloprost, administered for 7 to 28 days (1).…”

ACC/AHA 2005 Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): Executive Summary A Collaborative Report From the American Association for Vascular Surgery/Society for Vascular Surgery,⁎⁎AAVS/SVS when Guideline initiated, now merged into SVSSociety for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guideline

“…Therefore, the use of autogenous vein is also strongly favored for bypasses to the popliteal artery below the knee. Femoral tibial bypass grafting with autogenous vein should rarely be necessary for the treatment of intermittent claudication because of the increased risk of amputation associated with failure of In the 8 short-term trials of parenteral administration of PGE-1 or prostacyclin in patients with CLI, the results have been inconsistent and for the most part have not demonstrated efficacy, as defined by amelioration of pain or healing of ulcers (16,(121)(122)(123)(124)(125)(126)(127). In addition, there have been at least 11 randomized, placebo-controlled trials of intravenous PGE-1 or iloprost (16).…”

ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): Executive Summary

“…Bypasses to the tibial arteries with prosthetic material should be avoided at all costs for the treatment of the claudicant because of very high risks of graft failure and amputation. In the 8 short-term trials of parenteral administration of PGE-1 or prostacyclin in patients with CLI, the results have been inconsistent and for the most part have not demonstrated efficacy, as defined by amelioration of pain or healing of ulcers (16,(121)(122)(123)(124)(125)(126)(127). In addition, there have been at least 11 randomized, placebo-controlled trials of intravenous PGE-1 or iloprost (16).…”