A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers

Saldalamacchia, G.; Lapice, Emanuela; Cuomo, V.; Feo, Emma De; D'Agostino, Elio; Rivellese, A; Vaccaro, Olga

doi:10.1016/s0939-4753(04)80029-2

Cited by 61 publications

(92 citation statements)

References 6 publications

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“…He concluded that though in his study he treated the patients with PRF for a short time it showed good improvement. [8] Similarly, in our study, we found mean reduction of 85.51% in ulcer area at the end of 4 weeks in patients treated with PRF which is faster when compared to saline group.…”

Section: Discussionsupporting

confidence: 81%

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Comparison of efficacy of autologous platelet-rich fibrin versus saline dressing in chronic venous leg ulcers: A randomised controlled trial

Somani

Rai

2017

J Cutan Aesthet Surg

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Background:Venous leg ulcer is a chronic condition, and various treatment modalities are available. Platelet-rich fibrin (PRF) is one of the newer modalities and it contains fibroblast growth factor (GF), vascular endothelial GF, angiopoitin and platelet-derived GF which enhances the wound healing. Hence, we conducted a randomised controlled trial to compare the efficacy of PRF versus saline dressing in chronic venous leg ulcers.Aim:This study aims to compare the efficacy of autologous PRF with saline dressing in patients with chronic venous leg ulcer and to compare the mean reduction in ulcer area at the end of 4 weeks.Materials and Methods:Fifteen patients with chronic venous leg ulcers of >6 months duration having an ulcer area of 1 cm × 1 cm to 5 cm × 5 cm were taken into the study and were randomly divided into two groups. Group 1: Patients received PRF dressing. Ten millilitres of patient's blood was taken and centrifuged at 3000 rpm for 15 min. A fibrin clot obtained in the middle of the tube was removed and used for dressing over the wound surface. It was repeated every week for 4 weeks. Group 2: Patients received saline dressings once a week for 4 weeks. The assessment of the ulcer size was done with the help of photographs, and ulcer area was measured.Results:The mean reduction in the area of the ulcer size in PRF group was 85.51%, and the mean reduction in the area of the ulcer size in Saline group was 42.74% which was statistically significant with a P < 0.001 and t = 4.11.Conclusion:We conclude that PRF dressing can be used as it is effective, inexpensive, safe and an outpatient procedure.

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Section: Discussionsupporting

confidence: 81%

“…[5789] Our study showed 42.74% reduction in ulcer size when treated with saline dressing, however, this was less when compared to the 85.51% ulcer area reduction in the PRF dressing group.…”

Section: Discussionmentioning

confidence: 71%

Comparison of efficacy of autologous platelet-rich fibrin versus saline dressing in chronic venous leg ulcers: A randomised controlled trial

Somani

Rai

2017

J Cutan Aesthet Surg

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“…This initial product, known as platelet-derived wound healing factors (PDWHF) stimulated the formation of the vascularised connective tissue found in healing wounds. Thereafter various other types of platelets products have been assayed in several pilot studies, case series and clinical trials [41][42][43].…”

Section: Treatment Of Chronic Ulcersmentioning

confidence: 99%

The potential impact of the preparation rich in growth factors (PRGF) in different medical fields☆

et al. 2007

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“…18,19 The procedure to generate autologous PLT gel is impractical for expanded use and difficult to standardize. Different patients have different PLT profiles and different methods produce dramatic differences in PLT yield and effect.…”

mentioning

confidence: 99%

“…9,18,19 Although some mixed results were reported, several studies about the use of PLT concentrates or gel showed accelerated bone regeneration, reduced inflammation, decreased blood loss, reduced postoperative narcotic requirements, and improved hard and soft tissue wound healing. 9,18,19 PLTs have a very short life at room temperature (RT; 7 days) and incur storage damage, albeit by different mechanisms, when stored at RT, in the cold 20 or frozen states. 21 Moreover, federally regulated storage limitations apply to PLTs incorporated in wound-healing applications, although PLTs retain the ability to induce proliferation for up to 3 weeks.…”

mentioning

confidence: 99%

Wound‐healing properties of trehalose‐stabilized freeze‐dried outdated platelets

Sum¹,

Hager²,

Pietramaggiori

et al. 2007

Transfusion

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A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers

Cited by 61 publications

References 6 publications

Comparison of efficacy of autologous platelet-rich fibrin versus saline dressing in chronic venous leg ulcers: A randomised controlled trial

Comparison of efficacy of autologous platelet-rich fibrin versus saline dressing in chronic venous leg ulcers: A randomised controlled trial

The potential impact of the preparation rich in growth factors (PRGF) in different medical fields☆

Wound‐healing properties of trehalose‐stabilized freeze‐dried outdated platelets

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