A controlled study for gender selection

Jaffe, Sharon B.; Jewelewicz, Raphael; Wahl, Eric; Khatamee, M.

doi:10.1016/s0015-0282(16)54481-1

Cited by 29 publications

(9 citation statements)

References 16 publications

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“…We also observed fewer non-Caucasian and non-US-origin couples who presented desiring females since there is a cultural preference for males in non-Western societies. This cultural difference was also demonstrated in our previous study [18]. Unfortunately, the demographics are incomplete since not every respondent answered the questions and some information was not available in the patient files.…”

Section: Discussionsupporting

confidence: 53%

A Controlled Study for Gender Selection Using Swim-Up Separation

Khatamee

Horn²,

Weseley³

et al. 1999

Gynecol Obstet Invest

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Objective: To evaluate the success for gender selection using a sample of semen separated by a modified swim-up technique. Design: We retrospectively compared the gender outcome of two treatments (A and B) for either a male or female offspring with those who conceived spontaneously. Setting: Private practice of one author (M.A.K.). Patients, Participants: The treatment groups consisted of 52 total pregnancies for couples who conceived by the separation technique. Of these 52 participants, 15 desired a female offspring and were placed into treatment A and 37 desired a male offspring and were placed into treatment B. The control groups consisted of 162 women who were presented with initial consultation for gender selection and conceived spontaneously. Control group A consisted of 80 women who initially chose a female offspring, and control group B consisted of 82 participants who initially chose a male. Interventions: In treatment group A, one timed intrauterine insemination (IUI) was carried out with the bottom 0.5 ml of the separated semen on cycle days 12–14, when the follicle was 18–22 mm. Patients in this group were also administered clomiphene citrate and human chorionic gonadotropin. In treatment group B, one timed IUI was done with the top 0.5 ml of the separated semen, when the follicle was 18–22 mm. Main Outcome Measure: The gender outcome of the pregnancies of two treatment and control groups was evaluated based on the known desired gender. Results: The success rate for conceiving a female child after intervention (treatment group A) was 86.7% effective (p = 0.002) as compared to the control group A. Couples seeking a male child (treatment group B) were 89.2% effective (p = 0.0002) as compared to the control group B. Conclusions: This study reveals that the modified swim-up method with additional monitoring results in statistically significant gender preselection.

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Section: Discussionsupporting

confidence: 53%

A Controlled Study for Gender Selection Using Swim-Up Separation

Khatamee

Horn²,

Weseley³

et al. 1999

Gynecol Obstet Invest

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“…Ericsson et al reported that by doing this method, more than 85% of the Y-carrying spermatozoids were enriched (4). But in the studies conducted by, Ross et al (5), Vidal et al (7), to separate the sperms using gradient albumin and single lable FISH method, the above method was considered ineffective in the enrichment of the Y-carrying sperms (7,(17)(18)(19)(20)(21). Also in a study conducted by Wang et al in 1994 using the double lable FISH method, it was reported that the gradient albumin did not enrich Ychromosome carrying sperms (13).…”

Section: Discussionmentioning

confidence: 99%

“…In a study conducted in 1997 using two methods of protocol 3 and modified protocol 3 albumin gradient and double lable FISH method, Flaherty et al showed that no enrichment created in the Y-chromosome carrying sperms and the average ratio of X to Y sperm was 1.01 (14). In Jaffe et al study, the success rate in achieving male gender and female gender was reported to be over 55% and 78%, respectively (18). In another study conducted by Silverman et al, clomiphene citrate was used during ovulation induction; the results showed that the baby's birth rate with girl gender was 74% (19).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Separation of X- and Y-Chromosome Bearing Sperms of Fertile Men by Albumin Gradients Using Real Time PCR

Baheri

Saki

Asl

et al. 2016

Jentashapir J Health Res

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“…On the one hand the pH of vaginal fluid may result in different chance for conception of spermatozoa with X or Y chromosome. For example, the less acidic vaginal pH may prefer the transfer of spermatozoa including Y chromosome (Jaffe et al 1987;Czeizel et al 2010). On the other hand there is robust prenatal selection of fetuses and it may depend on their sex.…”

Section: Discussionmentioning

confidence: 99%

“…For example, the less acidic vaginal pH may prefer the transfer of spermatozoa including Y chromosome (Jaffe et al. ; Czeizel et al. ).…”

Section: Discussionmentioning

confidence: 99%

Sex ratio of congenital abnormalities in the function of maternal age: A population‐based study

Csermely¹,

Czeizel

Veszprémi

2015

Congenital Anomalies

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Maternal age effect is well-known in the origin of numerical chromosomal aberrations and some isolated congenital abnormalities (CAs). The sex ratio (SR), i.e. number of males divided by the number of males and females together, of most CAs deviates from the SR of newborn population (0.51). The objective of this analysis was to evaluate the possible association of maternal age with the SR of isolated CAs in a population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. First, SR of 24 CA entities/groups was estimated in 21 494 patients with isolated CA. In the next step SR of different maternal age groups was compared to the mean SR of the given CA-groups. The SR of four CA-groups showed some deviation in certain maternal age groups. Cases with anencephaly had female excess in young mothers (<25 years). Cases with skull's CAs particularly craniosynostosis had a male excess in cases born to women over 30 years. Two other CA groups (cleft lip ± palate and valvar pulmonic stenosis within the group of right-sided obstructive defect of heart) had significant deviation in SR of certain maternal age groups from the mean SR, but these deviations were not harmonized with joining age groups and thus were considered as a chance effect due to multiple testing. In conclusion, our study did not suggest that in general SR of isolated CAs might be modified by certain maternal age groups with some exception such as anencephaly and craniosynostosis.

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A controlled study for gender selection

Cited by 29 publications

References 16 publications

A Controlled Study for Gender Selection Using Swim-Up Separation

A Controlled Study for Gender Selection Using Swim-Up Separation

Assessment of the Separation of X- and Y-Chromosome Bearing Sperms of Fertile Men by Albumin Gradients Using Real Time PCR

Sex ratio of congenital abnormalities in the function of maternal age: A population‐based study

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