A controlled exploratory investigation into the effects of Thorazine upon mental test scores of chronic hospitalized schizophrenics

Neuroleptics: Effects on Neuropsychological Function in Chronic Schizophrenic Patients

“…Small et al 1972;Fredericks and Finkel 1978). Inconsistent findings on Object Assembly (Abrams 1958;Nickols 1958;Killian et al 1984), Picture Completion (Gardner et al 1955Abrams 1958;Nickols 1958;Pearl 1962;Killian et al 1984) In contrast to the above findings, improved performance after chronic administration of CPZ has been observed on two subtests of the Wechsler-Bellevue or the WAIS, Block Design and Picture Arrangement.…”

Tranquilizers and experimental psychopathology: A comment.

“…The alternate interpretation seems to receive support from the compatible results of a study of relatively acute subjects (Castner, Covington, & Nickols, 1958), and one of chronic schizophrenic subjects (Nickols, 1957(Nickols, , 1958. Both groups made considerable improvement in Wechsler Performance, but not in Verbal scores.…”

Rorschach Z scores on disturbed subjects.

“…Most of these Ss were diagnosed schizophrenic, but no attempt was made to control for diagnosis because Levine and Spivack (1959) found similarly significant correlations between Rorschach variables on intelligence and Wechsler IQ for hospitalized schizophrenics and nonschizophrenics. Neither was short-term or moderate use of tranquilizers viewed as a significant factor when the Rorschach and Wechsler Scales are employed as the evaluative criteria in research (cf., Nickols, 1958Nickols, , 1959Nickols, , & 1962.…”