A Controlled Clinical Trial of Prophylactic Folic Acid and Iron in Pregnancy

Chisholm, Morag

doi:10.1111/j.1471-0528.1966.tb05145.x

Cited by 56 publications

(40 citation statements)

References 12 publications

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“…However, in spite of the high prevalence of folate deficiency and of the biological effects of the treatment, there was no obvious correlation between folate status (or folate treatment) and the haematological data, these data being similar at delivery in both groups, one treated by iron alone and the other by the association of iron and folic acid. Other authors have pre viously described similar results: folate treatment does not increase the effect of iron supplementation during pregnancy [12,13] and does not pre vent the anaemia of pregnancy when given alone [1,14].…”

Section: Discussionsupporting

confidence: 59%

Influence of Routine Administration of Folic Acid and Iron during Pregnancy

Blot

Papiernik

Kaltwasser

et al. 1981

Gynecol Obstet Invest

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Haematological and folic acid status were assessed in 200 women in the 6th month of pregnancy. Folic acid deficiencies with no or little haematological impairment were found in one third of the cases, and their occurrence increased when the socioeconomic level was low. During the last trimester of pregnancy, the women were given either iron alone or iron and folic acid supplementation. In the mothers, the rise of folate values in serum and red blood cells, in the folic acid-supplemented group, had no obvious haematological consequences, showing that iron therapy alone can, in developed countries, prevent the anaemia in pregnancy. In the infants, there was no difference in the haematological indices, whatever the mothers’ treatment had been. However, a significant difference appeared for the gestational age and, therefore, the height and weight. Folic acid supplementation during pregnancy increased its duration by virtually 1 week.

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Section: Discussionsupporting

confidence: 59%

Influence of Routine Administration of Folic Acid and Iron during Pregnancy

Blot

Papiernik

Kaltwasser

et al. 1981

Gynecol Obstet Invest

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“…Some studies indicate a decrease in mean birth weight at term in infants of women with iron deficiency (Chisholm, 1966;Whalley et al, 1969), while others report no such correlation (Kitay and Harbort, 1975). An increase in the incidence of prematurity has been reported in iron deficiency (Scott, 1962), but no significant evidence exists linking iron deficiency with congenital anomalies.…”

Section: Ironmentioning

confidence: 94%

“…Supplementation of pregnant women with folic acid increases serum folic acid levels (Chisholm, 1966) and reduces the incidence of macrocytosis (Fleming et ai., 1974) but has not been shown to have any effect on hemoglobin levels (Chisholm, 1966;Fleming et at., 1974;Iyengar and Rajalakshmi, 1975).…”

Section: Folatementioning

confidence: 99%

Nutrition and Pregnancy

Rosso

Cramoy

1979

Nutrition

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“…The median level of B-type natriuretic peptide (BNP) in normal pregnant woman is about twice that of nonpregnant control subjects, rising early in pregnancy and remaining high throughout gestation [16][17][18] until ≈72 hours after delivery. 19,20 Adverse maternal cardiac events have been associated with high BNP concentrations (>100 pg/mL), but its use as a negative predictive indicator appears to be of most value.…”

Section: B-type Natriuretic Peptidementioning

confidence: 99%

Management of Pregnancy in Patients With Complex Congenital Heart Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association

Canobbio¹,

Warnes²,

Aboulhosn³

et al. 2017

Circulation

335

303

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Today, most female children born with congenital heart disease will reach childbearing age. For many women with complex congenital heart disease, carrying a pregnancy carries a moderate to high risk for both the mother and her fetus. Many such women, however, do not have access to adult congenital heart disease tertiary centers with experienced reproductive programs. Therefore, it is important that all practitioners who will be managing these women have current information not only on preconception counseling and diagnostic evaluation to determine maternal and fetal risk but also on how to manage them once they are pregnant and when to refer them to a regional center with expertise in pregnancy management.

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A Controlled Clinical Trial of Prophylactic Folic Acid and Iron in Pregnancy

Cited by 56 publications

References 12 publications

Influence of Routine Administration of Folic Acid and Iron during Pregnancy

Influence of Routine Administration of Folic Acid and Iron during Pregnancy

Nutrition and Pregnancy

Management of Pregnancy in Patients With Complex Congenital Heart Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association

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