A contribution to the study of the structure-mutagenicity relationship for α-dicarbonyl compounds using the Ames test

Determination of Carbonyl Compounds Generated from the E-cigarette Using Coupled Silica Cartridges Impregnated with Hydroquinone and 2,4-Dinitrophenylhydrazine, Followed by High-Performance Liquid Chromatography

“…Glyoxal is known to be mutagenic to Salmonella typhimurium strains TA100, TA102, and TA104. 6,7 It has been shown that glyoxal reacts with guanine residues in DNA. 8 Its tumor promoting activity has also been reported.…”

Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH

“…However, a recent study in neuroblastoma and other human cell lines has indicated that both the 2,3-hexanedione and 3,4-hexanedione are considerably more acutely cytotoxic than the 2,5 derivative over 4 and 24 h (Woehrling et al, 2006). In addition, 2,3-hexanedione was shown to induce mitotic chromosomal loss in the presence of an inducer of chromosomal malsegregation (Zimmermann and Mohr, 1992) and the 3,4 derivative was mildly mutagenic in the Ames test (Dorado et al, 1992). Therefore, this study has been undertaken to determine if the ␣-diketone derivatives are equitoxic in terms of their functional cytotoxicity and effects on the DNA cell cycle in SK-N-SH cells, a human neuroblastoma line, which is an established indicator of human neural cytotoxicity.…”

Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acet

“…The EFSA Journal (2009) (Nagao et al, 1986) Reverse mutation S. typhimurium TA100 220-500 µg/plate Positive d (Dorado et al, 1992) Reverse mutation E. coli WP2uvrA/pKM101 NR Positive d Chromosomal aberration Chinese hamster ovary cells 10-50 µg/ml Positive (Nishi et al, 1989) Chromosomal aberration Human lymphocytes 320 µg/ml Positive b (Migliore et al, 1990) Sister chromatid exchange Chinese hamster ovary cells 7.2 µg/ml Negative (Tucker et al, 1989) Sister chromatid exchange Chinese hamster ovary cells 14-36 µg/ml Positive (Tucker et al, 1989) Sister chromatid exchange Chinese hamster ovary cells 7.2-54 µg/ml Positive (Faggin et al, 1985) Sister chromatid exchange Human lymphocytes 320 µg/ml Positive b (Migliore et al, 1990) Micronucleus formation Human lymphocytes 320 µg/ml Positive b (Migliore et al, 1990) DNA strand breaks Calf thymus DNA NR Positive (Rahman et al, 1990) Micronucleus formation Rat 400 mg/kg bw e Negative (Martelli et al, 1989) Micronucleus formation Rat 800 mg/kg bw f Positive (Martelli et al, 1989) Sister chromatid exchange Mice duodenal cells 400 mg/kg bw Negative (Migliore et al, 1990) 07.001 937…”