A CONTRIBUTION TO THE PROBLEM OF AUTOSENSITTZATION TN BRONCHIAL ASTHMA¹

Increased IgG Antibody-Induced Cytotoxicity Against Airway Epithelial Cells in Patients with Nonallergic Asthma

“…Approximately 50 years ago, Bergquist and Mendes respectively suggested that autoimmunity might be an important pathogenetic mechanism underlying the [19,20]. Many trials have attempted to provide supporting evidences for this hypothesis by demonstrating the presence of various autoantibodies against antigens in the bronchial mucosa, paranasal sinus, lung, and endothelial cells in patients with asthma, especially in patients with nonallergic asthma [9][10][11].…”

Autoimmune Mechanism in Diseases of the Respiratory Tract

“…Bcrgqu'ist (3) suggests that the autoimmune mechanism may be a secondary factor in addition to allergy in bronchial asthma. Alendf.…”

Pathologic Manifestations of Allergic and Related Mechanisms in Diseases of the Lungs

“…The last item, auto-immune disease, is of very great known importance for the localization of allergic disease of the renal and nervous system and for the destruction of specific types of blood cells, but its relationship to allergic diseases of the lung is just beginning to be studied. Bergquist (6) has reported that respiratory mucous membrane on which staphylococci have been grown can acquire allergenic properties, and that he has detected auto-antibodies to this tissue in many asthmatics by means of skin tests and, in a few, he has also demonstrated this fact by the Prausnitz-Kiistner technic.…”