Autoimmune Mechanism in Diseases of the Respiratory Tract

Wagner, V.; Tomsíková, A; ŠACil, J.; Janková, J.; Novácková, D

doi:10.1111/j.1398-9995.1965.tb03350.x

Cited by 12 publications

(10 citation statements)

References 7 publications

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“…The idea of a possible involvement of autoimmunity in the pathogenesis of asthma has been proposed by earlier studies that demonstrated higher incidences of various autoantibodies against antigens in bronchial mucosa, paranasal sinus, lung, endothelial cells, and nuclei in patients with asthma, compared with healthy control subjects (7)(8)(9)(17)(18)(19). However, these observations could not establish a causal relationship between autoimmunity and asthma, partly due to lack of an identified autoantigen or lack of a logical association between these autoantibodies and airway inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…The idea of the possible involvement of an autoimmune mechanism in the pathogenesis of asthma has been proposed by previous studies that demonstrated high incidences of circulating autoantibodies to bronchial mucosa tissue in patients with asthma, especially in patients with nonallergic asthma (7,8). The presence of circulating IgG autoantibodies to the 55-kD antigen of endothelial cells has also been reported in patients with nonallergic asthma (9).…”

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confidence: 99%

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Identification of Cytokeratin 18 as a Bronchial Epithelial Autoantigen Associated with Nonallergic Asthma

Nahm

Lee

Yim

et al. 2002

Am J Respir Crit Care Med

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The allergic response to common environmental agents (allergens) has been regarded as an important mechanism in the development of airway inflammation of patients with asthma. However, allergic sensitization cannot be detected in a significant number of adult patients with asthma. The etiologic mechanism responsible for nonallergic asthma has not yet been identified. The idea of a possible involvement of autoimmunity in the pathogenesis of nonallergic asthma has been proposed by earlier studies. To test for the possible presence of an autoimmune response to bronchial epithelial cell antigens in nonallergic asthma, we examined circulating autoantibodies to cultured human bronchial epithelial cells (BEAS-2B) in sera from patients with nonallergic asthma by immunoblot analysis. IgG autoantibodies to the 49-kD bronchial epithelial cell antigen were detected in 10 of 23 patients with nonallergic asthma (43%), 3 of 27 patients with allergic asthma (11%), 2 of 20 patients with systemic lupus erythematosus (10%), and 3 of 34 healthy volunteers (9%) (p Ͻ 0.005). The 49-kD autoantigen was purified and identified as cytokeratin 18 by amino acid sequencing. In this study, we identified cytokeratin 18 as a bronchial epithelial autoantigen associated with nonallergic asthma. Further studies are needed to determine the significance of autoimmunity in nonallergic asthma.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Identification of Cytokeratin 18 as a Bronchial Epithelial Autoantigen Associated with Nonallergic Asthma

Nahm

Lee

Yim

et al. 2002

Am J Respir Crit Care Med

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“…Approximately 50 years ago, Bergquist and Mendes respectively suggested that autoimmunity might be an important pathogenetic mechanism underlying the [19,20]. Many trials have attempted to provide supporting evidences for this hypothesis by demonstrating the presence of various autoantibodies against antigens in the bronchial mucosa, paranasal sinus, lung, and endothelial cells in patients with asthma, especially in patients with nonallergic asthma [9][10][11]. Analysis of T cells in the airway fluids from patients with nonatopic asthma have shown features of clonal expansion, which indicates an antigen-induced activation of T cells in the airway [21].…”

Section: Discussionmentioning

confidence: 99%

“…The "autoimmune hypothesis" of nonallergic asthma is based on the frequent detection of circulating autoantibodies to lung or bronchial mucosa tissue in patients with asthma, particularly nonallergic asthma [9][10][11]. The titers of autoantibodies to lung tissue in serum samples from asthmatic patients were correlated with asthma severity and paralleled serial changes in disease state [12].…”

Section: Introductionmentioning

confidence: 99%

Increased IgG Antibody-Induced Cytotoxicity Against Airway Epithelial Cells in Patients with Nonallergic Asthma

et al. 2009

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Background IgG autoantibodies to airway epithelial cell proteins have been detected in patients with nonallergic asthma. Objective and Methods To evaluate the functional significance of these autoantibodies, we examined the presence of IgG antibody-induced cytotoxicity against airway epithelial cells (A549) by the microcytotoxicity assay using IgG antibodies purified from patients with nonallergic asthma. Results IgG antibody-induced cytotoxicity (expressed as percent cell lysis) was significantly increased in nine patients with nonallergic asthma (mean ± standard deviation; 30.6±7.3%) as compared with eight healthy controls (13.9±5.1%) and nine patients with allergic asthma (20.3± 10.4%; p<0.05). In addition, IgG antibody-induced cytotoxicity was significantly inhibited when IgG antibodies from patients with nonallergic asthma were pre-incubated with recombinant human airway epithelial cell autoantigens (cytokeratin 18 or alpha-enolase proteins; p<0.05). Conclusion These results suggest a possible involvement of IgG autoantibody-induced cytotoxicity against airway epithelial cells in the pathogenesis of nonallergic asthma.

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“…2 It has been repeatedly suggested that autoimmune mechanism might be involved in the pathogenesis of asthma, especially in nonallergic asthma. [4][5][6] The autoimmune hypothesis of asthma is based on the presence of autoantibodies to the target tissue of inflammation (lung and bronchial mucosa), 6 common genetic association, frequent coexistence with autoimmune diseases, 7,8 and response to the medications used for systemic autoimmune diseases such as systemic corticosteroid, cyclosporin A, intravenous Igs, and anti-TNF reagents. 9,10 ChurgStrauss syndrome is a distinct form of systemic vasculitis characterized by pre-existing adult-onset severe asthma and sudden development of pulmonary infiltrates, peripheral blood eosinophilia, paranasal sinus abnormality, neuropathy, and frequent presence of antineutrophil cytoplasmic antibodies.…”

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confidence: 99%