A contribution to pharmaceutical biology of freshwater sponges

Talevska, Aleksandra; Pejin, Boris; Kojić, Vesna; Berić, Tanja; Stanković, Slavka

doi:10.1080/14786419.2017.1315719

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Although mostly marine sponges are in the focus of interest, freshwater animals also synthesize numerous active compounds. The acetone extract of the freshwater sponge Ochridaspongia rotunda manifested cytotoxic and antiradical activities; however, the extract did not induce DNA breaks [ 57 ]. Similarly, the extract of the marine sponge Agelas oroides produced cytotoxic effects and induced reactive oxygen species (ROS) formation and apoptosis but did not induce DNA breaks [ 58 ].…”

Section: Results Of Literature Searchmentioning

confidence: 99%

A Review on Genotoxic and Genoprotective Effects of Biologically Active Compounds of Animal Origin

Sjakste

Gajski

2023

Toxins

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Envenomation by animal venoms remains a serious medical and social problem, especially in tropical countries. On the other hand, animal venoms are widely used as a source of biologically active compounds for the development of novel drugs. Numerous derivatives of animal venoms are already used in clinical practice. When analysing the mechanisms of action of animal venoms, attention is usually focused on the main target of the venom’s enzymes and peptides such as neurotoxic, cytotoxic or haemorrhagic effects. In the present review, we would like to draw attention to the “hidden” effects of animal venoms and their derivatives in regard to DNA damage and/or protection against DNA damage. Alkaloids and terpenoids isolated from sponges such as avarol, ingenamine G or variolin B manifest the capability to bind DNA in vitro and produce DNA breaks. Trabectidin, isolated from a sea squirt, also binds and damages DNA. A similar action is possible for peptides isolated from bee and wasp venoms such as mastoparan, melectin and melittin. However, DNA lesions produced by the crude venoms of jellyfish, scorpions, spiders and snakes arise as a consequence of cell membrane damage and the subsequent oxidative stress, whereas certain animal venoms or their components produce a genoprotective effect. Current research data point to the possibility of using animal venoms and their components in the development of various potential therapeutic agents; however, before their possible clinical use the route of injection, molecular target, mechanism of action, exact dosage, possible side effects and other fundamental parameters should be further investigated.

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Section: Results Of Literature Searchmentioning

confidence: 99%

A Review on Genotoxic and Genoprotective Effects of Biologically Active Compounds of Animal Origin

Sjakste

Gajski

2023

Toxins

View full text Add to dashboard Cite

show abstract

“…Those are either endemic or ubiquitous [61] and belong to the single monophyletic order Spongilina [101]. Until now, only a few studies focused on bacteria related to these freshwater sponges and their potential in small molecule production [16,41,43,42,84,85,46,71]. Even though different bacterial strains belonging to the phyla Actinobacteria and Proteobacteria were isolated from freshwater sponges before, no strain has been characterized and validly described [46,4,44,70].…”

Section: Introductionmentioning

confidence: 99%